Institute of Cell Biophysics, RAS, Pushchino, Moscow Region 142290, Russia.
Institute of Theoretical and Experimental Biophysics, RAS, Pushchino, Moscow Region 142290, Russia.
Life Sci Space Res (Amst). 2021 Feb;28:18-21. doi: 10.1016/j.lssr.2020.11.002. Epub 2020 Nov 26.
The maintenance of pharmacological torpor and hypothermia (body temperature 28 °C - 33 °C) in rats for a week is presented. For this purpose, our laboratory has developed a device (BioFeedback-2) for the feed-back controlled multiple injections of small doses of a pharmacological composition that we created earlier. On the 7th day, the rat spontaneously come out of the pharmacological torpor, the body temperature returned to normal, and on the 8th day, the animal could consume food and water. The proposed approach for maintaining multi-day pharmacological torpor can be applied in medicine, as well as for protecting astronauts during long missions in space.
本文介绍了一种在大鼠体内维持药理学休眠和低温（体温 28°C-33°C）一周的方法。为此，我们实验室开发了一种设备（BioFeedback-2），用于反馈控制多次注射我们之前创建的小剂量药理学组合物。第 7 天，大鼠自发地从药理学休眠中苏醒，体温恢复正常，第 8 天，动物可以进食和饮水。所提出的维持多天药理学休眠的方法可应用于医学，以及在宇航员进行长期太空任务时进行保护。
