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范可尼贫血-比克尔综合征致低骨密度患者行粒细胞和单核细胞吸附性白细胞去除术治疗溃疡性结肠炎

Granulocyte and Monocyte Adsorptive Apheresis for Ulcerative Colitis in a Patient with Low Bone Mineral Density Due to Fanconi-Bickel Syndrome.

机构信息

Department of Gastroenterology and Hepatology, Saiseikai Shigaken Hospital, Imperial Gift Foundation Inc., Japan.

Department of Diagnostic Pathology, Saiseikai Shigaken Hospital, Imperial Gift Foundation Inc., Japan.

出版信息

Intern Med. 2021 Aug 1;60(15):2413-2417. doi: 10.2169/internalmedicine.6707-20. Epub 2021 Feb 22.

DOI:10.2169/internalmedicine.6707-20
PMID:33612684
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8381163/
Abstract

Systemic steroid is required for the exacerbation of ulcerative colitis (UC), although its administration should be avoided in patients with a low bone mineral density (BMD) exacerbated by side effects of steroids. We herein report the successful induction of remission in an UC case with a low BMD due to Fanconi-Bickel syndrome-or glycogen storage disease type XI-using granulocyte and monocyte adsorptive apheresis (GMA). For a 43-year-old woman with a BMD of 50% the young adult mean, GMA was performed 2 times a week for a total of 10 times. GMA might be a steroid-free treatment option for UC patients with a low BMD.

摘要

系统性类固醇是溃疡性结肠炎（UC）恶化所必需的，尽管对于因类固醇副作用而导致骨密度（BMD）降低的患者，应避免使用类固醇。我们在此报告了一例由于范可尼-比克尔综合征或糖原贮积病 XI 型导致低 BMD 的 UC 病例，使用粒细胞和单核细胞吸附性血浆分离术（GMA）成功诱导缓解。对于一名 43 岁的女性，其 BMD 为年轻人平均值的 50%，每周进行 2 次 GMA，共进行 10 次。GMA 可能是 BMD 降低的 UC 患者的一种无类固醇治疗选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/149e/8381163/5d2e2fab1d53/1349-7235-60-2413-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/149e/8381163/5ba639da148c/1349-7235-60-2413-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/149e/8381163/4c519480f2a1/1349-7235-60-2413-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/149e/8381163/014db6e29204/1349-7235-60-2413-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/149e/8381163/f0158b03dd62/1349-7235-60-2413-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/149e/8381163/5d2e2fab1d53/1349-7235-60-2413-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/149e/8381163/5ba639da148c/1349-7235-60-2413-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/149e/8381163/4c519480f2a1/1349-7235-60-2413-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/149e/8381163/014db6e29204/1349-7235-60-2413-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/149e/8381163/f0158b03dd62/1349-7235-60-2413-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/149e/8381163/5d2e2fab1d53/1349-7235-60-2413-g005.jpg

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