Department of Parasitology and Animal Diseases, National Research Centre, Dokki, Giza, Egypt.
Trop Biomed. 2020 Dec 1;37(4):1018-1028. doi: 10.47665/tb.37.4.1018.
The present study was conducted to detect the therapeutic effect of Moringa oleifera and Thymus vulgaris oils on hepatic coccidiosis in experimentally infected rabbits. Also, immunomodulatory effect of the two oils was detected. Twenty-four Newzealand rabbits were used in this study and divided into 4 groups; healthy rabbits, experimentally infected rabbits with Eimeria stiedae oocysts, and two infected treated groups (one with moringa (200 mg/kg) and the other with thyme (500 mg/kg) oils). The results showed highly significant reduction in oocysts shedding (P<0.001 and P<0.05) in the two infected and treated rabbits than the infected non-treated rabbits in almost all days post infection (PI). Thyme oil was more potent and stopped oocysts shedding earlier at the day 34 PI compared to moringa oil at the day 41 PI. Microscopically, there was a damage in the oocysts shed by treated rabbits. Macroscopically, the livers of thyme oil treated rabbits showed more enhancement with protection percentage 75% than those treated with moringa oil in which protection percentage was 55%. The highest titer of antibodies was detected in moringa oil treated rabbits. It was concluded that both moringa and thyme oils had an anti-coccidial effect with thyme oil superiority. So, thyme oil could be useful as an alternative product for the control of rabbit coccidiosis.
本研究旨在检测辣木和麝香草油对实验感染兔球虫病的治疗效果。同时，还检测了这两种油的免疫调节作用。本研究使用了 24 只新西兰兔，将其分为 4 组：健康兔、用艾美耳球虫卵囊实验感染的兔、以及用辣木（200mg/kg）和麝香草（500mg/kg）油处理的两组感染兔。结果表明，与未处理的感染兔相比，在感染后几乎所有的日子（PI），两种感染和处理的兔的卵囊脱落量均显著减少（P<0.001 和 P<0.05）。麝香草油比辣木油更早地停止卵囊脱落，在第 34 天 PI 时，而辣木油在第 41 天 PI 时。镜下，处理兔的卵囊脱落受到损伤。宏观上，与用辣木油处理的兔相比，用麝香草油处理的兔的肝脏显示出更高的增强作用，保护率为 75%，而用辣木油处理的兔的保护率为 55%。用辣木油处理的兔的抗体滴度最高。综上所述，辣木和麝香草油都具有抗球虫作用，而麝香草油具有优势。因此，麝香草油可以作为控制兔球虫病的替代产品。
