Clouet P M, Bourre J M
Unité de Neurotoxicologie, INSERM Unité 26, Hôpital Fernand Widal, Paris, France.
J Neurochem. 1988 May;50(5):1494-7. doi: 10.1111/j.1471-4159.1988.tb03035.x.
This work demonstrates that in vitro sciatic nerves of normal and trembler adult mice can use ketone bodies (beta-hydroxybutyrate and acetoacetate) and butyrate for lipid synthesis. In normal sciatic nerves, beta-hydroxybutyrate is incorporated in total lipids to a larger extent than acetoacetate (141% and 33%, respectively, of acetate incorporation), whereas for trembler sciatic nerves, these percentages are only 69% and 27%. Incorporation of ketone bodies is greater into sterols than into other lipids. Lipid metabolism of ketone bodies in trembler nerves is altered and could reflect a process similar to Wallerian degeneration: a dramatic decrease of sterol and free fatty acid synthesis and an increased synthesis of triglycerides. Moreover, differences seen in precursor incorporation into lipids between normal and trembler sciatic nerves suggest that their lipid metabolism is not the same.
这项研究表明，正常成年小鼠和震颤成年小鼠的体外坐骨神经能够利用酮体（β-羟基丁酸酯和乙酰乙酸）和丁酸进行脂质合成。在正常坐骨神经中，β-羟基丁酸酯掺入总脂质的程度比乙酰乙酸更大（分别为乙酸掺入量的141%和33%），而对于震颤小鼠的坐骨神经，这些百分比仅为69%和27%。酮体掺入甾醇的量比掺入其他脂质的量更多。震颤神经中酮体的脂质代谢发生了改变，这可能反映了一个类似于华勒氏变性的过程：甾醇和游离脂肪酸合成急剧减少，甘油三酯合成增加。此外，正常和震颤小鼠坐骨神经在脂质前体掺入方面的差异表明它们的脂质代谢并不相同。
