EB 病毒与系统性红斑狼疮中的自身免疫反应。

Epstein Barr Virus and Autoimmune Responses in Systemic Lupus Erythematosus.

机构信息

Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States.

Departments of Medicine, Pathology, Microbiology & Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.

出版信息

Front Immunol. 2021 Feb 3;11:623944. doi: 10.3389/fimmu.2020.623944. eCollection 2020.

DOI:10.3389/fimmu.2020.623944

PMID:33613559

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7886683/

Abstract

Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease. Infections or infectious reactivation are potential triggers for initiation of autoimmunity and for SLE flares. Epstein-Barr virus (EBV) is gamma herpes virus that has been associated with several autoimmune diseases such as SLE, multiple sclerosis, Sjogren's syndrome, and systemic sclerosis. In this review, we will discuss the recent advances regarding how EBV may contribute to immune dysregulation, and how these mechanisms may relate to SLE disease progression.

摘要

系统性红斑狼疮（SLE）是一种复杂的系统性自身免疫性疾病。感染或感染再激活是自身免疫和 SLE 发作的潜在诱因。EB 病毒（EBV）是一种γ疱疹病毒，与多种自身免疫性疾病有关，如 SLE、多发性硬化症、干燥综合征和系统性硬化症。在这篇综述中，我们将讨论 EBV 如何导致免疫失调的最新进展，以及这些机制与 SLE 疾病进展的关系。