Department of Endocrinology and Metabolism, Laboratory of Endocrinology and Metabolism, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Department of Integrated Traditional Chinese and Western Medicine, Laboratory of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China.
Front Immunol. 2021 Feb 4;11:625034. doi: 10.3389/fimmu.2020.625034. eCollection 2020.
The complex crosstalk between the immune and the skeletal systems plays an indispensable role in the maintenance of skeletal homeostasis. Various cytokines are involved, including interleukin (IL)-17A. A variety of immune and inflammatory cells produces IL-17A, especially Th17 cells, a subtype of CD4 T cells. IL-17A orchestrates diverse inflammatory and immune processes. IL-17A induces direct and indirect effects on osteoclasts. The dual role of IL-17A on osteoclasts partly depends on its concentrations and interactions with other factors. Interestingly, IL-17A exerts a dual role in osteoblasts . IL-17A is a bone-destroying cytokine in numerous immune-mediated bone diseases including postmenopausal osteoporosis (PMOP), rheumatoid arthritis (RA), psoriatic arthritis (PsA) and axial spondylarthritis (axSpA). This review will summarize and discuss the pathophysiological roles of IL-17A on the skeletal system and its potential strategies for application in immune-mediated bone diseases.
免疫系统和骨骼系统之间的复杂串扰在维持骨骼内稳态中起着不可或缺的作用。各种细胞因子参与其中，包括白细胞介素（IL）-17A。多种免疫和炎症细胞产生 IL-17A，特别是 Th17 细胞，这是 CD4 T 细胞的一种亚型。IL-17A 协调多种炎症和免疫过程。IL-17A 对破骨细胞产生直接和间接的影响。IL-17A 对破骨细胞的双重作用部分取决于其浓度及其与其他因素的相互作用。有趣的是，IL-17A 在成骨细胞中发挥双重作用。IL-17A 是许多免疫介导的骨病中的骨破坏细胞因子，包括绝经后骨质疏松症（PMOP）、类风湿关节炎（RA）、银屑病关节炎（PsA）和轴性脊柱关节炎（axSpA）。本综述将总结和讨论 IL-17A 在骨骼系统中的病理生理作用及其在免疫介导的骨病中的潜在应用策略。
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