Food Microbiology Division, Food Safety Evaluation Department, National Institute of Food and Drug Safety Evaluation, Cheongju, South Korea.
College of Agriculture and Life Sciences, Kangwon National University, Chuncheon, South Korea.
Front Cell Infect Microbiol. 2021 Feb 4;10:596570. doi: 10.3389/fcimb.2020.596570. eCollection 2020.
spp. are the leading global cause of bacterial colon infections in humans. Enteropathogens are subjected to several stress conditions in the host colon, food complexes, and the environment. Species of the genus , in collective interactions with certain enteropathogens, can manage and survive such stress conditions. The stress-adaptation mechanisms of spp. diverge from other enteropathogenic bacteria, such as , serovar Typhi, ser. Paratyphi, ser. Typhimurium, and species of the genera and . This review summarizes the different mechanisms of various stress-adaptive factors on the basis of species diversity in , including their response to various stress conditions that enhance their ability to survive on different types of food and in adverse environmental conditions. Understanding how these stress adaptation mechanisms in , and other enteric bacteria, are used to overcome various challenging environments facilitates the fight against resistance mechanisms in spp., and aids the development of novel therapeutics to control in both veterinary and human populations.
spp. 是全球导致人类细菌性结肠感染的主要原因。肠道病原体在宿主结肠、食物复合物和环境中会受到多种压力条件的影响。属中的某些物种与某些肠道病原体共同作用,可以应对和存活于这些压力条件下。 spp. 的应激适应机制与其他肠道致病菌(如伤寒血清型 Typhi、副伤寒血清型 Paratyphi、血清型 Typhimurium 以及属 和 的物种)不同。本综述根据属中的物种多样性,总结了不同应激适应因子的不同机制,包括它们对各种应激条件的反应,这些条件增强了它们在不同类型食物和不利环境条件下生存的能力。了解这些属和其他肠道细菌中的应激适应机制如何被用来克服各种具有挑战性的环境,有助于对抗 spp. 中的耐药机制,并有助于开发新型治疗方法来控制兽医和人类群体中的 。