Bouw M C, Nij Bijvank S W A, Bouwhuis J W, van Wezel-Meijler G
Department of Neonatology, Isala Women and Children's Hospital, Zwolle, Netherlands.
Department of Obstetrics and Gynecology, Isala Women and Children's Hospital, Zwolle, Netherlands.
Front Pediatr. 2021 Feb 5;8:622597. doi: 10.3389/fped.2020.622597. eCollection 2020.
Obstetric Antiphospholipid Syndrome (OAPS) is an autoimmune disease characterized by certain pregnancy complications in association with persistent antiphospholipid antibodies. These antibodies are generally known for their prothrombotic characteristics and may affect mother and fetus during the entire pregnancy. The clinical criteria for OAPS, including recurrent fetal loss, intra-uterine growth restriction and premature birth due to severe preeclampsia, all suggest uteroplacental vascular insufficiency. Although rare, thrombotic complications have been described in neonates born to mothers with OAPS, mainly ischemic stroke. We report on the first case of extensive fetal intraventricular related to OAPS. We share our diagnostic search and analysis for this unusual antenatal event, including cranial ultrasound findings and postmortem MRI images. We will also present a short review of the etiology and prognosis of antenatal intraventricular hemorrhage. We suggest that women with severe or early preeclampsia and/or a history of pregnancy loss should be evaluated for OAPS and carefully monitored throughout pregnancy. Further, we advise to test mothers for OAPS in the case of idiopathic fetal hemorrhage.
产科抗磷脂综合征（OAPS）是一种自身免疫性疾病，其特征为某些妊娠并发症与持续存在的抗磷脂抗体相关。这些抗体通常以其促血栓形成特性而闻名，在整个孕期可能会影响母亲和胎儿。OAPS的临床标准，包括反复胎儿丢失、宫内生长受限以及因重度子痫前期导致的早产，均提示子宫胎盘血管功能不全。虽然罕见，但在患有OAPS的母亲所生的新生儿中已描述有血栓形成并发症，主要是缺血性中风。我们报告了首例与OAPS相关的广泛胎儿脑室内病变病例。我们分享了针对这一不寻常产前事件的诊断探索与分析，包括头颅超声检查结果和尸检MRI图像。我们还将简要回顾产前脑室内出血的病因和预后。我们建议，对于患有重度或早期子痫前期和/或有流产史的女性，应评估其是否患有OAPS，并在整个孕期进行仔细监测。此外，对于特发性胎儿出血的情况，我们建议对母亲进行OAPS检测。
