Xu Jing, Huang Yan, Zhao Jimeng, Wu Luyi, Qi Qin, Liu Yanan, Li Guona, Li Jing, Liu Huirong, Wu Huangan
Yueyang Hospital of Integrative Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Key Laboratory of Acupuncture and Immunological Effects, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Front Cell Dev Biol. 2021 Feb 4;9:599065. doi: 10.3389/fcell.2021.599065. eCollection 2021.
Cofilin is an actin-binding protein that regulates filament dynamics and depolymerization. The over-expression of cofilin is observed in various cancers, cofilin promotes cancer metastasis by regulating cytoskeletal reorganization, lamellipodium formation and epithelial-to-mesenchymal transition. Clinical treatment of cancer regarding cofilin has been explored in aspects of tumor cells apoptosis and cofilin related miRNAs. This review addresses the structure and phosphorylation of cofilin and describes recent findings regarding the function of cofilin in regulating cancer metastasis and apoptosis in tumor cells.
丝切蛋白是一种肌动蛋白结合蛋白，可调节细丝动力学和解聚。在各种癌症中均观察到丝切蛋白的过表达，丝切蛋白通过调节细胞骨架重组、片状伪足形成和上皮-间质转化促进癌症转移。关于丝切蛋白的癌症临床治疗已在肿瘤细胞凋亡和丝切蛋白相关的微小RNA方面进行了探索。本文综述了丝切蛋白的结构和磷酸化，并描述了关于丝切蛋白在调节肿瘤细胞癌症转移和凋亡功能方面的最新发现。
