Krautter Franziska, Iqbal Asif J
Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, United Kingdom.
Front Cell Dev Biol. 2021 Feb 4;9:624082. doi: 10.3389/fcell.2021.624082. eCollection 2021.
Leukocyte recruitment is a highly controlled cascade of interactions between proteins expressed by the endothelium and circulating leukocytes. The involvement of glycans and glycan-binding proteins in the leukocyte recruitment cascade has been well-characterised. However, our understanding of these interactions and their regulation has expanded substantially in recent years to include novel lectins and regulatory pathways. In this review, we discuss the role of glycans and glycan-binding proteins, mediating the interactions between endothelium and leukocytes both directly and indirectly. We also highlight recent findings of key enzymes involved in glycosylation which affect leukocyte recruitment. Finally, we investigate the potential of glycans and glycan binding proteins as therapeutic targets to modulate leukocyte recruitment and transmigration in inflammation.
白细胞募集是内皮细胞表达的蛋白质与循环白细胞之间一系列高度受控的相互作用。聚糖和聚糖结合蛋白在白细胞募集级联反应中的作用已得到充分表征。然而，近年来我们对这些相互作用及其调节的理解有了很大扩展，包括新型凝集素和调节途径。在这篇综述中，我们讨论了聚糖和聚糖结合蛋白直接和间接介导内皮细胞与白细胞之间相互作用的作用。我们还强调了参与糖基化的关键酶的最新发现，这些酶会影响白细胞募集。最后，我们研究了聚糖和聚糖结合蛋白作为治疗靶点来调节炎症中白细胞募集和迁移的潜力。
