University of California, Davis.
Ghent University.
Child Dev. 2021 May;92(3):e285-e295. doi: 10.1111/cdev.13471. Epub 2020 Dec 8.
Two independent cohorts (N = 155, N = 126) of infants at high and low risk for autism spectrum disorder (ASD) were followed prospectively between 6 and 36 months of age, when n = 46 were diagnosed with ASD. Gaze to adult faces was coded-during a developmental assessment (Cohort 1) or a play interaction (Cohort 2). Across both cohorts, most children developing ASD showed sharp declines in gaze to faces over time, relative to children without ASD. These findings suggest that declining developmental trajectories may be more common than previously recognized by retrospective methods. Trajectory-based screening methods could potentially identify children in the early stages of symptom onset and allow for early intervention before the full disorder has developed.
两个独立的队列（高风险自闭症谱系障碍（ASD）队列 N=155，低风险 ASD 队列 N=126）的婴儿在 6 到 36 个月之间进行了前瞻性随访，期间有 46 名婴儿被诊断为 ASD。在发展评估（队列 1）或游戏互动（队列 2）期间对婴儿注视成人面孔的行为进行了编码。在两个队列中，与没有 ASD 的儿童相比，大多数患有 ASD 的儿童的面部注视随时间推移而急剧下降。这些发现表明，与以前使用回顾性方法相比，下降的发展轨迹可能更为常见。基于轨迹的筛查方法可以潜在地识别出症状发作早期的儿童，并在全面发病前进行早期干预。
