Key Laboratory of Science & Technology of Eco-Textile, Ministry of Education, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, P. R. China.
Macromol Biosci. 2021 Apr;21(4):e2100007. doi: 10.1002/mabi.202100007. Epub 2021 Feb 22.
Design of intelligent hybrid nanoparticles that can integrate diagnosis and therapy components plays an important role in the field of nanomedicine. Poly(amidoamine) (PAMAM) dendrimers possessing a unique architecture and tunable functional groups have been widely developed for various biomedical applications. Carbon dots (CDs) are considered as a promising fluorescence probe or drug delivery system due to their stable fluorescence property and excellent biocompatibility. The distinctive merits of PAMAM dendrimers and CDs are amenable for them to be constructed as perfect nanohybrids for different biomedical applications, in particular for cancer nanomedicine. Here, the recent advances in the construction of PAMAM dendrimer/CD nanohybrids for diverse biomedical applications, in particular for sensing and cancer theranostics are summarized. Finally, the future perspectives of the PAMAM dendrimer/CD nanohybrids are also briefly discussed.
智能杂化纳米粒子的设计，能够整合诊断和治疗组件，在纳米医学领域发挥着重要作用。具有独特结构和可调官能团的聚酰胺-胺（PAMAM）树枝状大分子已被广泛开发用于各种生物医学应用。由于其稳定的荧光性质和优异的生物相容性，碳点（CDs）被认为是一种很有前途的荧光探针或药物传递系统。PAMAM 树枝状大分子和 CDs 的独特优点使得它们可以构建成用于不同生物医学应用的完美纳米杂化物，特别是用于癌症纳米医学。本文总结了近年来用于各种生物医学应用，特别是用于传感和癌症治疗的 PAMAM 树枝状大分子/CD 纳米杂化物的构建进展。最后，还简要讨论了 PAMAM 树枝状大分子/CD 纳米杂化物的未来展望。
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