生活在阳光充足地区的心力衰竭患者的维生素 D 状态及其 25-羟维生素 D 水平的预测因素。

Vitamin D status and predictors of 25-hydroxyvitamin D levels in patients with heart failure living in a sunny region.

机构信息

Postgraduate Program in Nutrition. Centro de Ciências da Saúde. Universidade Federal do Rio Grande do Norte.

Empresa Brasileira de Serviços Hospitalares, Hospital Universitário Onofre Lopes. Centro de Ciências da Saúde. Universidade Federal do Rio Grande do Norte.

出版信息

Nutr Hosp. 2021 Apr 19;38(2):349-357. doi: 10.20960/nh.03291.

DOI:10.20960/nh.03291

PMID:33615819

Abstract

Aims: hypovitaminosis D has frequently been identified in patients with heart failure (HF). However, few studies have been conducted in regions with high solar incidence. Therefore, this study aimed to evaluate vitamin D status and predictors of 25-hydroxyvitamin D (25(OH)D) levels in patients with HF living in a sunny region (5 °- 6 °S). Methods: this cross-sectional study enrolled 70 patients with HF. Biodemographic, clinical, biochemical, dietary, and sun exposure data were collected, and 25(OH)D levels were measured. Results: the mean 25(OH)D level was 40.1 (12.4) ng/mL, and 24.3 % (95 % CI: 14.2-33.8) of patients with HF had hypovitaminosis D (25(OH)D < 30 ng/mL). Female patients (p = 0.001), those with ischemic etiology (p = 0.03) and those with high parathyroid hormone levels (> 67 pg/mL) (p = 0.034) were more likely to present hypovitaminosis D. Higher 25(OH)D levels were observed in men than in women (β = 7.78, p = 0.005) and in patients with HF in New York Heart Association (NHYA) functional class I when compared to those in class III/IV (β = 8.23, p = 0.032). Conclusions: the majority of patients with HF had sufficient 25(OH)D levels. Sex and functional classification were identified as independent predictors of 25(OH)D levels. These results highlight the need for increased monitoring of vitamin D status among female patients with heart failure and those with more severe symptoms.

摘要

目的

维生素 D 缺乏症在心力衰竭（HF）患者中经常被发现。然而，在阳光充足的地区进行的研究较少。因此，本研究旨在评估生活在阳光充足地区（5°-6°S）的 HF 患者的维生素 D 状况和 25-羟维生素 D（25（OH）D）水平的预测因素。

方法

这是一项横断面研究，共纳入 70 例 HF 患者。收集了生物统计学、临床、生化、饮食和日照数据，并测量了 25（OH）D 水平。

结果

25（OH）D 平均水平为 40.1（12.4）ng/mL，24.3%（95%CI：14.2-33.8）的 HF 患者存在维生素 D 缺乏症（25（OH）D < 30 ng/mL）。女性患者（p=0.001）、缺血性病因患者（p=0.03）和甲状旁腺激素水平较高（>67 pg/mL）患者（p=0.034）更易出现维生素 D 缺乏症。男性患者的 25（OH）D 水平高于女性（β=7.78，p=0.005），纽约心脏协会（NYHA）心功能 I 级患者的 25（OH）D 水平高于 III/IV 级患者（β=8.23，p=0.032）。