Hagău Asmaa Carla, Pușcaș Amalia, Togănel Rodica, Muntean Iolanda
Doctoral School of Medicine and Pharmacy, I.O.S.U.D., George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Emergency Institute for Cardiovascular Diseases and Transplantation of Târgu Mureș, 540136 TarguMures, Romania.
Department of Biochemistry and Chemistry of Environmental Factors, Faculty of Pharmacy, University of Medicine, Pharmacy, Science and Technology "George Emil Palade" of Targu Mures, 540142 Targu Mures, Romania.
Life (Basel). 2023 Jan 29;13(2):372. doi: 10.3390/life13020372.
Several studies in recent years have shown the association between vitamin D levels and heart failure. Vitamin D deficiency is related to increased cardiovascular morbidity and mortality, with a higher risk of developing heart failure. In this systematic review, we aimed to assess recent studies that analyzed vitamin D deficiency and heart failure in adult and pediatric populations. (2) Methods: We conducted a systematic search for studies published in the following databases: PubMed and Scopus from January 2012 to October 2022. (3) Results: Most observational studies that were included found a significant association between hypovitaminosis D and heart failure. However, the beneficial role of vitamin D supplementation is still controversial due to the lack of randomized controlled trials. (4) Conclusions: Vitamin D may play an important role as a cardiovascular marker in heart failure patients. More well-designed studies are needed to investigate the relationship between vitamin D and heart failure and to determine if vitamin D supplementation could improve long-term outcomes.
近年来的多项研究表明了维生素D水平与心力衰竭之间的关联。维生素D缺乏与心血管发病率和死亡率增加相关，患心力衰竭的风险更高。在这项系统评价中，我们旨在评估近期分析成人和儿童人群中维生素D缺乏与心力衰竭的研究。（2）方法：我们对2012年1月至2022年10月在以下数据库中发表的研究进行了系统检索：PubMed和Scopus。（3）结果：纳入的大多数观察性研究发现维生素D缺乏与心力衰竭之间存在显著关联。然而，由于缺乏随机对照试验，维生素D补充剂的有益作用仍存在争议。（4）结论：维生素D可能作为心力衰竭患者的心血管标志物发挥重要作用。需要更多设计良好的研究来调查维生素D与心力衰竭之间的关系，并确定补充维生素D是否可以改善长期预后。
