Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, People's Republic of China.
Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China.
Laryngoscope. 2021 Aug;131(8):1798-1804. doi: 10.1002/lary.29433. Epub 2021 Feb 22.
OBJECTIVES/HYPOTHESIS: The routine practices of examining submucosal lesions are not suitable for deep lesions. Therefore, we evaluated the efficacy of non-real-time image-guided transnasal endoscopic fine-needle aspiration biopsy (FNAB) in diagnosing nasopharyngeal carcinoma (NPC) with submucosal lesions.
The effectiveness evaluation of diagnostic methods.
Fifty suspected NPC patients who failed in conventional biopsies were enrolled in this study. The efficacy, maneuverability, and safety of FNAB in diagnosing these intractable cases were evaluated.
The definitive diagnostic results of these 50 patients were NPC (34/50, 68.0%), nasopharyngeal necrosis (1/50, 2.0%), nasopharyngeal mucositis (12/50, 24.0%), and other cancers (3/50, 6.0%), respectively. The results of the diagnostic efficacy of FNAB were sensitivity, 89.2%; specificity, 100.0%; positive predictive value, 100.0%; negative predictive value, 76.5%; and accuracy, 92.0%, respectively. The area under the receiver operating characteristic curves was 0.946 (95% confidence interval = 0.884-1.00, P < .001). No severe complications occurred after FNAB.
FNAB can improve the diagnostic efficiency of NPC occurring in the submucosal space. It can be an additional option for routine nasopharyngeal biopsy and is worthy of clinical application.
4 Laryngoscope, 131:1798-1804, 2021.
目的/假设：黏膜下病变的常规检查方法并不适用于深部病变。因此，我们评估了非实时图像引导经鼻内镜细针抽吸活检（FNAB）在诊断黏膜下病变的鼻咽癌（NPC）中的疗效。
诊断方法的效果评估。
本研究纳入了 50 例常规活检失败的疑似 NPC 患者。评估了 FNAB 对这些难治性病例的诊断效能、可操作性和安全性。
这 50 例患者的明确诊断结果分别为 NPC（34/50，68.0%）、鼻咽坏死（1/50，2.0%）、鼻咽黏膜炎（12/50，24.0%）和其他癌症（3/50，6.0%）。FNAB 的诊断效能结果分别为：灵敏度 89.2%、特异性 100.0%、阳性预测值 100.0%、阴性预测值 76.5%和准确率 92.0%。受试者工作特征曲线下面积为 0.946（95%置信区间 0.884-1.00，P<.001）。FNAB 后无严重并发症发生。
FNAB 可提高黏膜下空间 NPC 的诊断效率。它可以作为常规鼻咽活检的一种附加选择，值得临床应用。
4 级，《喉镜》，131：1798-1804，2021 年。
