长效第二代和口服抗精神病药物治疗物质使用障碍和精神病症状：意大利精神科医生的处方态度。
Long-acting second-generation and oral antipsychotics for substance use disorders and psychotic symptoms: Prescribing attitudes among Italian psychiatrists.
机构信息
Department of Neuroscience Imaging and Clinical Science, "G. d'Annunzio" University of Chieti, Chieti, Italy.
Department of Pharmacy, Pharmacology and Clinical Science, University of Hertfordshire, Herts, UK.
出版信息
Perspect Psychiatr Care. 2021 Oct;57(4):1700-1706. doi: 10.1111/ppc.12738. Epub 2021 Feb 22.
PURPOSE
To explore Italian psychiatrists' attitudes toward the off-label use of second generation antipsychotics (SGAs) in patients with substance use disorder and psychotic symptoms.
DESIGN AND METHODS
A sample of 300 Italian psychiatrists associated with the Italian Society of Neuropsychopharmacology was randomly selected to complete a survey about the off-label prescription of SGAs.
FINDINGS
Oral aripiprazole (32.7%), olanzapine (30.2%), and quetiapine (25.2%) were considered "appropriate." Long-acting antipsychoticss were generally considered "inappropriate."
PRACTICE IMPLICATIONS
Our findings reflect a substantial level of uncertainty and a lack of coherent clinical guidance within the realm of dual diagnosis treatment. Therefore, they emphasize the need to develop specific guidelines to improve the management of pharmacotherapy among this population.
目的
探讨意大利精神科医生对第二代抗精神病药物（SGAs）在物质使用障碍和精神病症状患者中的超说明书使用的态度。
方法
随机抽取意大利神经精神药理学学会的 300 名意大利精神病医生组成样本，完成一份关于 SGAs 超说明书处方的调查。
结果
口头给予阿立哌唑（32.7%）、奥氮平（30.2%）和喹硫平（25.2%）被认为是“合适的”。长效抗精神病药物通常被认为是“不合适的”。
实践意义
我们的研究结果反映了在双重诊断治疗领域存在相当程度的不确定性和缺乏一致的临床指导。因此，它们强调需要制定具体的指南，以改善这一人群的药物治疗管理。
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