中性粒细胞与淋巴细胞比值可作为伊朗 COVID-19 患者不良预后的预测因子。

Neutrophil-to-Lymphocyte Ratio as a Poor Prognostic Factor in Iranian COVID-19 Patients.

出版信息

Clin Lab. 2021 Feb 1;67(2). doi: 10.7754/Clin.Lab.2020.200726.

DOI:10.7754/Clin.Lab.2020.200726

Abstract

BACKGROUND

We aimed to accumulate evidence that suggests the potential role of neutrophil-to-lymphocyte ratio (NLR) in determining the prognostic factor for COVID-19 patients.

METHODS

A cohort of COVID-19 hospitalized patients at the Ilam University of Medical Sciences was analyzed. Logistic regression models were performed to identify the potential role of NLR in determining the prognostic factor for COVID-19 patients.

RESULTS

The total number of in-hospital mortality was 43/328 (13.1%). Multivariate analysis identified that there was a 26% higher risk of in-hospital death for each unit increase in NLR (Odds ratio [OR] = 1.08; 95% confidence interval [95% CI], 1.01 to 1.14; p = 0.0147). Multivariate analysis identified that there was an 8% higher risk of in-hospital death for each unit increase in NLR (Odds ratio [OR] = 1.08; 95% confidence interval [95% CI], 1.01 to 1.14; p = 0.0147). Compared with patients in the NLR < 5 group, the NLR of patients in the NLR ≥ 5 group had a 16-fold higher risk of mortality (OR = 16.04; 95% CI, 1.14 to 224.95; p = 0.0395) after adjustment for potential confounders.

CONCLUSIONS

NLR is an independent risk factor of mortality COVID-19 patients.

摘要

背景

我们旨在积累证据，提示中性粒细胞与淋巴细胞比值（NLR）在确定 COVID-19 患者预后因素方面的潜在作用。

方法

分析了伊拉姆医科大学住院的 COVID-19 患者队列。采用逻辑回归模型来确定 NLR 在确定 COVID-19 患者预后因素方面的潜在作用。

结果

住院死亡总人数为 43/328（13.1%）。多变量分析确定，NLR 每增加一个单位，住院死亡的风险就会增加 26%（优势比[OR] = 1.08；95%置信区间[95%CI]，1.01 至 1.14；p = 0.0147）。多变量分析确定，NLR 每增加一个单位，住院死亡的风险就会增加 8%（优势比[OR] = 1.08；95%置信区间[95%CI]，1.01 至 1.14；p = 0.0147）。与 NLR<5 组的患者相比，NLR≥5 组的患者死亡风险增加了 16 倍（OR = 16.04；95%CI，1.14 至 224.95；p = 0.0395），校正了潜在混杂因素后。