Wang Jinmin, Qu Xianglong, Zhao Limin, Yan Bing
Shanghai Key Lab of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Tongji University, Shanghai 200092, China.
School of Materials Science and Engineering, Liaocheng University, Liaocheng 252059, China.
Anal Chem. 2021 Mar 9;93(9):4308-4316. doi: 10.1021/acs.analchem.0c05309. Epub 2021 Feb 22.
Covalent organic framework (COF) nanosheets (NSs) are a new member in the family of two-dimensional (2D) nanomaterials that received increasing attention. The ability to prepare COF NSs with rapid acquisition is of great importance to explore their distinctive properties and potential applications. Herein, we elaborate design a new COF hybrid material EB-TFP:Eu(BTA) as a sensing platform. In the process of ratiometric fluorescence detection of 5-fluorouracil (5FU), an anticancer drug, we realize the preparation of COF NSs. Interaction occurs between 5FU and COF hybrid material, where the interlayer π-π stacking of COF was weakened, benefiting the exfoliation of bulk COF to acquire 2D COF NSs. This strategy provides not only a sensitive and selective 5FU sensor but also a significant inspiration for engineering 2D COF NSs.
共价有机框架（COF）纳米片（NSs）是二维（2D）纳米材料家族中受到越来越多关注的新成员。能够快速制备COF NSs对于探索其独特性能和潜在应用非常重要。在此，我们精心设计了一种新型COF杂化材料EB-TFP:Eu(BTA)作为传感平台。在对抗癌药物5-氟尿嘧啶（5FU）进行比率荧光检测的过程中，我们实现了COF NSs的制备。5FU与COF杂化材料之间发生相互作用，其中COF的层间π-π堆积减弱，有利于块状COF的剥离以获得二维COF NSs。该策略不仅提供了一种灵敏且选择性高的5FU传感器，还为二维COF NSs的工程化提供了重要启示。
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