Zhang Xiaojing, Zou Lina, Liao Hao, Ren Huanyu, Niu Huiru, Li Zheng, Zhang Xueqing, Huang Xiaojing, Liu Yanan, Zhou Zhiren, Pan Hongzhi, Ma Hongkun, Rong Shengzhong
Public Health School, Mudanjiang Medical University, Mudanjiang, China.
Nursing School, Mudanjiang Medical University, Mudanjiang, China.
Mikrochim Acta. 2025 Jan 23;192(2):103. doi: 10.1007/s00604-024-06822-2.
Natural enzymes are a class of biological catalysts that can catalyze a specific substrate. Although natural enzymes have catalytic activity, they are susceptible to the influence of external environment such as temperature, and storage requirements are more stringent. Since the first discovery of magnetic FeO nanoparticles with peroxidase-like activity in 2007, the research on nanoenzymes has entered a rapid development stage. Nanoenzymes synthesized by chemical methods not only have the catalytic activity of natural enzymes but also are more stable, easy to store, and convenient to prepare. Anthracyclines, as a commonly used anti-tumor chemotherapy drug, will produce many side effects such as myelosuppression and liver function damage after long-term use, which will affect its therapeutic effects. This paper reviews the characteristics, classification, and mechanisms of nanoenzymes. The detection of anti-tumor drugs, especially anthracycline drugs, using a nanoenzyme-based sensor was emphatically introduced. On this basis, the application of nanoenzyme-based sensors in the detection of anti-tumor drugs is prospected.
天然酶是一类能够催化特定底物的生物催化剂。虽然天然酶具有催化活性，但它们易受温度等外部环境的影响，储存要求更为严格。自2007年首次发现具有类过氧化物酶活性的磁性FeO纳米颗粒以来，纳米酶的研究进入了快速发展阶段。通过化学方法合成的纳米酶不仅具有天然酶的催化活性，而且更稳定、易于储存且制备方便。蒽环类药物作为常用的抗肿瘤化疗药物，长期使用后会产生骨髓抑制和肝功能损害等多种副作用，这将影响其治疗效果。本文综述了纳米酶的特性、分类和作用机制。着重介绍了基于纳米酶的传感器对抗肿瘤药物，尤其是蒽环类药物的检测。在此基础上，展望了基于纳米酶的传感器在抗肿瘤药物检测中的应用。
