Jerkins G R, Noe H N, Hill D
Department of Pediatric Urology, University of Tennessee, Memphis.
J Urol. 1988 May;139(5):923-5. doi: 10.1016/s0022-5347(17)42718-2.
Since 1976, 23 patients with cyclophosphamide-induced cystitis were treated. These patients presented with a variety of urinary problems, including incontinence, hematuria and vesicoureteral reflux. Vesicoureteral reflux was found in 9 patients, hydronephrosis in 4 and a contracted fibrotic bladder in 3. Of the 23 patients 18 had undergone a combination of radiation and cyclophosphamide therapy. Based on this experience a general outline is developed for evaluation and treatment of patients with cyclophosphamide-induced cystitis and its potentially severe complications.
自1976年以来，共治疗了23例环磷酰胺所致膀胱炎患者。这些患者出现了各种泌尿系统问题，包括尿失禁、血尿和膀胱输尿管反流。9例患者发现有膀胱输尿管反流，4例有肾积水，3例有膀胱纤维化挛缩。23例患者中有18例接受过放疗与环磷酰胺联合治疗。基于这一经验，制定了环磷酰胺所致膀胱炎及其潜在严重并发症患者的评估和治疗大纲。
