Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, USA.
Department of Pediatrics, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, USA.
J Clin Endocrinol Metab. 2021 May 13;106(6):1684-1691. doi: 10.1210/clinem/dgab115.
It is unclear how fat mass accretion in early life is related to glucose-insulin homeostasis.
Examine associations of fat and fat-free mass accretion from birth to early childhood with glucose-insulin homeostasis in early childhood in a multi-ethnic cohort.
Observational Healthy Start study with data collection from 2010 to 2020. Air displacement plethysmography at birth and 4.8 (SD 0.7) years estimated fat mass percent (FMP, %), fat mass index (FMI, kg/m2), and fat-free mass index (FFMI, kg/m2). General population recruited from academic obstetrics clinics in Denver, Colorado, consisting of 419 mother/offspring dyads. The main outcome measures were fasting glucose, insulin, homeostasis model assessment-2 insulin resistance (HOMA2-IR), and beta-cell function (HOMA2-B) at 4.8 years.
Greater fat mass accretion from birth to early childhood was associated with higher fasting glucose (ΔFMP β = 0.20 [95% CI 0.06-0.34], ΔFMI β = 0.90 [0.30-1.50]) in participants of Hispanic, Black, and Other races/ethnicities, while greater fat-free mass accretion was associated with higher fasting glucose in non-Hispanic White participants (ΔFFMI β = 0.76 [0.21-1.32]). Overall, greater fat, but not fat-free, mass accretion was also associated with higher insulin (ΔFMP β = 0.14 [0.09-0.18], ΔFMI 0.71 [0.51-0.92]), HOMA2-IR (FMP β = 0.02 [0.01-0.02], ΔFMI β = 0.09 [0.06-0.12]), and HOMA2-B (ΔFMP β = 0.92 [0.18-1.36], ΔFMI β = 4.76 [2.79-6.73]).
Greater fat mass accretion in infancy and childhood is associated with shifts in fasting glucose in children of Hispanic, Black, and Other races/ethnicities at 5 years of age. Body composition beginning in early life is relevant for metabolic health, and precise assessments of adiposity in pediatric research are needed.
目前尚不清楚生命早期脂肪量的增加与葡萄糖-胰岛素稳态之间有何关系。
在一个多民族队列中，研究从出生到幼儿期的脂肪和去脂体重增加与幼儿期葡萄糖-胰岛素稳态的关系。
这是一项 2010 年至 2020 年期间进行的数据收集的观察性健康启动研究。出生时和 4.8 岁（标准差 0.7）时使用空气置换体积描记法估计脂肪百分比（FMP）、脂肪质量指数（FMI，kg/m2）和去脂体重指数（FFMI，kg/m2）。该研究从科罗拉多州丹佛的学术妇产科诊所招募了一般人群，共包括 419 对母婴对子。主要观察指标为 4.8 岁时的空腹血糖、胰岛素、稳态模型评估-2 胰岛素抵抗（HOMA2-IR）和β细胞功能（HOMA2-B）。
西班牙裔、黑人和其他种族/民族的参与者中，从出生到幼儿期的脂肪量增加与空腹血糖升高相关（ΔFMPβ=0.20[95%CI0.06-0.34]，ΔFMIβ=0.90[0.30-1.50]），而非西班牙裔白种人参与者中，去脂体重增加与空腹血糖升高相关（ΔFFMIβ=0.76[0.21-1.32]）。总体而言，脂肪量的增加（ΔFMPβ=0.14[0.09-0.18]，ΔFMIβ=0.71[0.51-0.92]）而非去脂体重的增加与胰岛素（ΔFMPβ=0.14[0.09-0.18]，ΔFMIβ=0.71[0.51-0.92]）、HOMA2-IR（FMPβ=0.02[0.01-0.02]，ΔFMIβ=0.09[0.06-0.12]）和 HOMA2-B（ΔFMPβ=0.92[0.18-1.36]，ΔFMIβ=4.76[2.79-6.73]）也相关。
西班牙裔、黑人和其他种族/民族的儿童在 5 岁时，婴儿期和儿童期脂肪量增加与空腹血糖变化有关。生命早期的身体成分与代谢健康有关，因此需要在儿科研究中精确评估肥胖程度。
