Section on Nutrition, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Epigenomics. 2024;16(18):1215-1230. doi: 10.1080/17501911.2024.2359365. Epub 2024 Sep 12.
Assess if cord blood differentially methylated regions (DMRs) representing human metastable epialleles (MEs) associate with offspring adiposity in 588 maternal-infant dyads from the Colorado Health Start Study. DNA methylation was assessed via the Illumina 450K array (~439,500 CpG sites). Offspring adiposity was obtained via air displacement plethysmography. Linear regression modeled the association of DMRs potentially representing MEs with adiposity. We identified two potential MEs, , which associated with infant adiposity change and , which associated with infancy and childhood adiposity change. Nine DMRs annotating to genes that annotated to MEs associated with change in offspring adiposity (false discovery rate <0.05). Methylation of approximately 80% of DMRs identified associated with decreased change in adiposity.
评估来自科罗拉多健康启动研究的 588 对母婴对子中脐带血差异甲基化区域 (DMRs) 是否代表人类易变表等位基因 (MEs)，并与后代肥胖相关。通过 Illumina 450K 阵列评估 DNA 甲基化（~439,500 个 CpG 位点）。通过空气置换体描记术获得后代肥胖。线性回归模型研究了潜在代表 MEs 的 DMRs 与肥胖的关联。我们确定了两个潜在的 MEs， 和 ，它们分别与婴儿肥胖变化和婴儿和儿童肥胖变化相关。9 个 DMRs 注释到 ME 注释到与后代肥胖变化相关的基因，其假发现率<0.05。与肥胖变化减少相关的 DMRs 约有 80%被鉴定为甲基化。
