Papoff P, Whetham J C, Katz A, deVeber G A
Can Med Assoc J. 1977 Dec 3;117(11):1288-95.
Pregnancy in renal transplant recipients is common and, in spite of several potential problems, overall maternal and fetal outcome has been good in patients with transplants that are functioning well. The presence of renal impairment or hypertension, or both, usually leads to complications, especially in the mother. A patient is described who had a baseline creatinine clearance of about 35 mL/min-1.73 m2 and two successful pregnancies. Renal function deteriorated in the 3rd trimester of the first pregnancy but was reversible; permanent loss of function occurred in the 3rd trimester of the second pregnancy. The potential fetal and maternal risks and details of management of pregnant transplant recipients are reviewed.
肾移植受者怀孕很常见，尽管存在一些潜在问题，但对于移植肾功能良好的患者，总体母婴结局良好。肾功能损害或高血压或两者同时存在通常会导致并发症，尤其是在母亲身上。本文描述了一名患者，其基线肌酐清除率约为35 mL/min/1.73 m²，成功怀孕两次。第一次怀孕的孕晚期肾功能恶化，但可逆转；第二次怀孕的孕晚期出现了永久性肾功能丧失。本文回顾了怀孕的肾移植受者潜在的胎儿和母亲风险以及管理细节。
