Park Yong Seok, Moon Haein, Woo Je Moon, Min Jung Kee
Department of Ophthalmology, Ulsan University Hospital, University of Ulsan, College of Medicine, Ulsan, Republic of Korea.
Semin Ophthalmol. 2021 Apr 3;36(3):110-114. doi: 10.1080/08820538.2021.1889612. Epub 2021 Feb 22.
To investigate changes in the foveal avascular zone (FAZ) area and retinal vessel density (VD) in the macula of patients receiving multiple anti-vascular endothelial growth factor (VEGF) therapy for neovascular age-related macular degeneration (N-AMD).
This study included 54 eyes of 54 treatment-naïve N-AMD patients. Thirty-three eyes were treated with intravitreal aflibercept injections, and 21 eyes were treated with intravitreal ranibizumab injections. Unaffected fellow eyes (54 eyes) were used as controls. All image scans were acquired after the macular architecture had recovered with drying up of the subretinal fluid/hemorrhage after treatment.
Both the superficial and deep FAZ areas were significantly larger in the aflibercept group than in the control group. The VD was also significantly reduced in the aflibercept group.
Prolonged and repeated anti-VEGF therapy may cause an increase in the FAZ area and a decrease in the VD in patients with N-AMD, indicating ischemic damage.
研究接受多次抗血管内皮生长因子（VEGF）治疗的新生血管性年龄相关性黄斑变性（N-AMD）患者黄斑区无血管区（FAZ）面积和视网膜血管密度（VD）的变化。
本研究纳入54例初治N-AMD患者的54只眼。33只眼接受玻璃体内阿柏西普注射治疗，21只眼接受玻璃体内雷珠单抗注射治疗。将未受影响的对侧眼（54只眼）作为对照。所有图像扫描均在治疗后视网膜下液/出血吸收，黄斑结构恢复后进行。
阿柏西普组的浅层和深层FAZ面积均显著大于对照组。阿柏西普组的VD也显著降低。
长期反复抗VEGF治疗可能导致N-AMD患者FAZ面积增加和VD降低，提示存在缺血性损伤。
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