Toufeeq Shafak, Gottlob Irene, Tu Zhanhan, Proudlock Frank A, Pilat Anastasia
Oxford Eye Hospital, Level LG1 John Radcliffe Hospital, Headley Way, Headington, Oxford OX3 9DU, United Kingdom.
Ulverscroft Eye Unit, Department of Neuroscience, Psychology and Behaviour, University Of Leicester, University Road, Leicester, LE1 7RH, United Kingdom.
Invest Ophthalmol Vis Sci. 2022 May 2;63(5):33. doi: 10.1167/iovs.63.5.33.
Infantile nystagmus syndrome (INS) causes altered visual development and can be associated with abnormal retinal structure, to which vascular development of the retina is closely related. Abnormal retinal vasculature has previously been noted in albinism but not idiopathic infantile nystagmus. We compared the number and diameter of retinal vessels in participants with albinism (PWA) and idiopathic infantile nystagmus (PWIIN) with controls.
Fundus photography data from 24 PWA, 10 PWIIN, and 34 controls was analyzed using Automated Retinal Image Analyzer (ARIA) software on a field of analysis centered on the optic disc, the annulus of which extended between 4.2 mm and 8.4 mm in diameter.
Compared with controls, the mean number of arterial branches was reduced by 24% in PWA (15.5 vs. 20.3, P < 0.001), and venous branches were reduced in both PWA (29%; 12.9 vs. 18.2, P < 0.001) and PWIIN (17%; 15.1 vs. 18.2, P = 0.024). PWA demonstrated 7% thinner "primary" (before branching) arteries (mean diameter: 75.39 µm vs. 80.88 µm, P = 0.043), and 13% thicker (after branching) "secondary" veins (66.72 µm vs. 59.01 µm in controls, P = 0.009).
PWA and PWIIN demonstrated reduced retinal vessel counts and arterial diameters compared with controls. These changes in the superficial retinal vascular network may be secondary to underdevelopment of the neuronal network, which guides vascular development and is also known to be disrupted in INS.
婴儿眼球震颤综合征（INS）会导致视觉发育异常，并可能与视网膜结构异常相关，而视网膜血管发育与之密切相关。先前在白化病中已注意到视网膜血管异常，但在特发性婴儿眼球震颤中未见报道。我们比较了白化病患者（PWA）、特发性婴儿眼球震颤患者（PWIIN）和对照组的视网膜血管数量和直径。
使用自动视网膜图像分析仪（ARIA）软件，对24例PWA、10例PWIIN和34例对照组的眼底摄影数据进行分析，分析区域以视盘为中心，其环直径在4.2毫米至8.4毫米之间。
与对照组相比，PWA的动脉分支平均数量减少了24%（15.5对20.3，P<0.001），PWA（29%；12.9对18.2，P<0.001）和PWIIN（17%；15.1对18.2，P = 0.024）的静脉分支均减少。PWA的“初级”（分支前）动脉细7%（平均直径：75.39微米对80.88微米，P = 0.043），“次级”（分支后）静脉粗13%（对照组为59.01微米，PWA为66.72微米，P = 0.009）。
与对照组相比，PWA和PWIIN的视网膜血管数量和动脉直径减少。视网膜浅表血管网络的这些变化可能继发于神经网络发育不全，神经网络指导血管发育，且已知在INS中会受到破坏。
