成人囊性纤维化间歇与持续负荷运动训练。

Interval versus constant-load exercise training in adults with Cystic Fibrosis.

机构信息

Lane Fox Respiratory Service, Guy's and St Thomas' NHS Foundation Trust, London, UK; Centre of Human and Applied Physiological Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK; 1st Respiratory Medicine Department, "Sotiria" Hospital for Diseases of the Chest, National and Kapodistrian University of Athens Medical School, Athens, Greece.

1st Respiratory Medicine Department, "Sotiria" Hospital for Diseases of the Chest, National and Kapodistrian University of Athens Medical School, Athens, Greece; Thorax Research Foundation, Centre of Intensive Care and Emergency Thoracic Medicine, Athens, Greece; Faculty of Health and Life Sciences, Department of Sport, Exercise and Rehabilitation, Northumbria University Newcastle, Newcastle Upon Tyne, UK.

出版信息

Respir Physiol Neurobiol. 2021 Jun;288:103643. doi: 10.1016/j.resp.2021.103643. Epub 2021 Feb 19.

DOI:10.1016/j.resp.2021.103643

PMID:33618051

Abstract

BACKGROUND

The efficacy of interval exercise (IE) compared to constant-load exercise (CLE) training remains unsettled in adults with Cystic Fibrosis (CF).

METHODS

Twenty-four adults with CF were randomised to 30-min IE (100 % peak work capacity (WRpeak) for 30-s alternated with 40 % WRpeak for 30-s; n = 12) or 30-min CLE (70 % WRpeak; n = 12) training, 3 times weekly, for 12 weeks. Isometric quadriceps muscle strength was assessed using a strain gauge Myometer.

RESULTS

The magnitude of improvement in quadriceps muscle strength was greater (p = 0.037) in the IE (by 32 ± 13 Nm) compared to the CLE (by 23 ± 12 Nm) groups. Maximum inspiratory and expiratory mouth pressures were significantly improved only in the IE group (by 30 ± 10 cmHO; p = 0.009 and 13 ± 4 cmHO; p = 0.007, respectively). Arterial oxygen saturation during training was higher (p = 0.002) for IE (94 ± 1%) compared to CLE (91 ± 1%), whereas dyspnoea scores were lower (p = 0.001) for IE (3.8 ± 0.7) compared to CLE (5.9 ± 0.8) CONCLUSIONS: IE is superior to CLE in improving peripheral and respiratory muscle strength and preferable to CLE because it is associated with lower exercise-induced arterial oxygen desaturation and breathlessness.

摘要

背景

间歇性运动（IE）与恒负荷运动（CLE）训练相比，在囊性纤维化（CF）成人患者中的疗效仍未确定。

方法

24 名 CF 成人患者被随机分为 30 分钟 IE 组（100%峰值工作能力（WRpeak）持续 30 秒，然后与 40%WRpeak 交替持续 30 秒；n=12）或 30 分钟 CLE 组（70%WRpeak；n=12），每周 3 次，共 12 周。使用应变计 Myometer 评估等长股四头肌肌力。

结果

IE 组（增加 32±13 Nm）的股四头肌肌力改善幅度明显大于 CLE 组（增加 23±12 Nm）（p=0.037）。仅 IE 组的最大吸气和呼气口腔压力显著改善（分别增加 30±10 cmHO；p=0.009 和 13±4 cmHO；p=0.007）。IE 组在训练过程中的动脉血氧饱和度更高（p=0.002，94±1%），而 CLE 组更低（p=0.002，91±1%），IE 组的呼吸困难评分更低（p=0.001，3.8±0.7），而 CLE 组更高（5.9±0.8）。