Vogiatzis Ioannis, Terzis Gerasimos, Nanas Serafeim, Stratakos Grigoris, Simoes Davina C M, Georgiadou Olga, Zakynthinos Spyros, Roussos Charis
National & Kapodistrian University of Athens, Medical School, Thorax Foundation 3 Ploutarhou Str. 106 75, Athens, Greece.
Chest. 2005 Dec;128(6):3838-45. doi: 10.1378/chest.128.6.3838.
To investigate the response to interval exercise (IE) training by looking at changes in morphologic and biochemical characteristics of the vastus lateralis muscle, and to compare these changes to those incurred after constant-load exercise (CLE) training.
Randomized, controlled, parallel, two-group study (IE vs CLE training).
Multidisciplinary, outpatient, hospital-based, pulmonary rehabilitation program.
Nineteen patients with stable advanced COPD (mean +/- SEM FEV1, 40 +/- 4% predicted).
Patients (n = 10) assigned to IE training exercised at a mean intensity of 124 +/- 15% of baseline peak exercise capacity (peak work rate [Wpeak]) with 30-s work periods interspersed with 30-s rest periods for 45 min/d. Patients (n = 9) allocated to CLE training exercised at a mean intensity of 75 +/- 5% Wpeak for 30 min/d. Patients exercised 3 d/wk for 10 weeks.
Needle biopsies of the right vastus lateralis muscle were performed before and after rehabilitation. After IE training, the cross-sectional areas of type I and IIa fibers were significantly increased (type I before, 3,972 +/- 455 microm2; after, 4,934 +/- 467 microm2 [p = 0.004]; type IIa before, 3,695 +/- 372 microm2; after, 4,486 +/- 346 microm2 [p = 0.008]), whereas the capillary-to-fiber ratio was significantly enlarged (from 1.13 +/- 0.08 to 1.24 +/- 0.07 [p = 0.013]). Citrate synthase activity increased (from 14.3 +/- 1.4 to 20.5 +/- 4.2 micromol/min/g), albeit not significantly (p = 0.097). There was also a significant improvement in Wpeak (by 19 +/- 5%; p = 0.04) and in lactate threshold (by 17 +/- 5%; p = 0.02). The magnitude of changes in all the above variables was not significantly different compared to that incurred after CLE training. During training sessions, however, ratings of dyspnea and leg discomfort, expressed as fraction of values achieved at baseline Wpeak, were significantly lower (p < 0.05) for IE training (73 +/- 9% and 60 +/- 8%, respectively) compared to CLE training (83 +/- 10% and 87 +/- 13%, respectively).
High-intensity IE training is equally effective to moderately intense CLE training in inducing peripheral muscle adaptations; however, IE is associated with fewer training symptoms.
通过观察股外侧肌形态学和生化特征的变化来研究间歇运动（IE）训练的反应，并将这些变化与持续负荷运动（CLE）训练后的变化进行比较。
随机、对照、平行、两组研究（IE与CLE训练）。
多学科、门诊、医院为基础的肺康复项目。
19例稳定期重度慢性阻塞性肺疾病患者（平均±标准误FEV1，预测值的40±4%）。
分配到IE训练组的患者（n = 10）以基线峰值运动能力（峰值工作率[Wpeak]）的124±15%的平均强度进行运动，工作30秒，穿插30秒休息，每天45分钟。分配到CLE训练组的患者（n = 9）以Wpeak的75±5%的平均强度每天运动30分钟。患者每周运动3天，共10周。
康复前后对右侧股外侧肌进行针吸活检。IE训练后，I型和IIa型纤维的横截面积显著增加（I型训练前，3972±455平方微米；训练后，4934±467平方微米[p = 0.004]；IIa型训练前，3695±372平方微米；训练后，4486±346平方微米[p = 0.008]），而毛细血管与纤维的比例显著增大（从1.13±0.08增至1.24±0.07[p = 0.013]）。柠檬酸合酶活性增加（从14.3±1.4增至20.5±4.2微摩尔/分钟/克），尽管差异不显著（p = 0.097）。Wpeak也有显著改善（提高19±5%；p = 0.04），乳酸阈值也有显著改善（提高17±5%；p = 0.02）。与CLE训练后相比，上述所有变量的变化幅度无显著差异。然而，在训练期间，与CLE训练（分别为83±10%和87±13%）相比，IE训练时的呼吸困难和腿部不适评分（以基线Wpeak时达到的值的分数表示）显著更低（p < 0.05）（分别为73±9%和60±8%）。
高强度IE训练在诱导外周肌肉适应方面与中等强度CLE训练同样有效；然而，IE训练相关的症状更少。
