Department of Internal Medicine and Endocrinology, Medical University of Warsaw, Warsaw.
Department of Internal Medicine and Endocrinology, Medical University of Warsaw, Warsaw; Department of Genomic Medicine, Medical University of Warsaw, Warsaw.
Cancer Treat Res Commun. 2021;27:100338. doi: 10.1016/j.ctarc.2021.100338. Epub 2021 Feb 17.
Cyclins are key regulators of cell cycle progression and survival. Particularly cyclins D (cyclin D1, D2, and D3) act in response to the mitogenic stimulation and are pivotal mediators between proliferative pathways and the nuclear cell cycle machinery. Dysregulation of cyclins expression results in impaired development, abnormal cell growth or tumorigenesis. In this review we summarize current knowledge about regulatory role of the cyclin D promoters, transcriptional factors: regulators, co-activators and adaptor proteins necessary to their activation. We focused on the intracellular signaling pathways vital to cell growth, differentiation and apoptosis including transcription factor families: activator protein 1 (AP1), nuclear factor (NFκB), signal transducer and activator of transcription (STAT), cAMP response element-binding protein (CREB) and Sp/NF-Y, with a special insight into the tissue specific cyclin representation.
细胞周期蛋白是细胞周期进程和存活的关键调节剂。特别是细胞周期蛋白 D（cyclin D1、D2 和 D3）对有丝分裂刺激作出反应，是增殖途径与核细胞周期机制之间的关键介质。细胞周期蛋白表达失调会导致发育不良、异常细胞生长或肿瘤发生。在这篇综述中，我们总结了细胞周期蛋白 D 启动子、转录因子的调节作用的最新知识：激活所必需的调节因子、共激活因子和衔接蛋白。我们专注于对细胞生长、分化和凋亡至关重要的细胞内信号通路，包括转录因子家族：激活蛋白 1（AP1）、核因子（NFκB）、信号转导和转录激活因子（STAT）、环腺苷酸反应元件结合蛋白（CREB）和 Sp/NF-Y，并特别关注组织特异性细胞周期蛋白的表达。
