Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea.
Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Diabetes Metab J. 2021 Sep;45(5):730-738. doi: 10.4093/dmj.2020.0154. Epub 2021 Feb 22.
The effect of intrauterine hyperglycemia on fat mass and regional fat proportion of the offspring of mothers with gestational diabetes mellitus (OGDM) remains to be determined.
The body composition of OGDM (n=25) and offspring of normoglycemic mothers (n=49) was compared using dualenergy X-ray absorptiometry at age 5 years. The relationship between maternal glucose concentration during a 100 g oral glucose tolerance test (OGTT) and regional fat mass or proportion was analyzed after adjusting for maternal prepregnancy body mass index (BMI).
BMI was comparable between OGDM and control (median, 16.0 kg/m2 vs. 16.1 kg/m2 ). Total, truncal, and leg fat mass were higher in OGDM compared with control (3,769 g vs. 2,245 g, P=0.004; 1,289 g vs. 870 g, P=0.017; 1,638 g vs. 961 g, P=0.002, respectively), whereas total lean mass was lower in OGDM (15,688 g vs. 16,941 g, P=0.001). Among OGDM, total and truncal fat mass were correlated with fasting and 3-hour glucose concentrations of maternal 100 g OGTT during pregnancy (total fat mass, r=0.49, P=0.018 [fasting], r=0.473, P=0.023 [3-hour]; truncal fat mass, r=0.571, P=0.004 [fasting], r=0.558, P=0.006 [3-hour]), but there was no correlation between OGDM leg fat mass and maternal OGTT during pregnancy. Regional fat indices were not correlated with concurrent maternal 75 g OGTT values.
Intrauterine hyperglycemia is associated with increased fat mass, especially truncal fat, in OGDM aged 5 years.
宫内高血糖对患有妊娠期糖尿病（OGDM）母亲的后代脂肪量和局部脂肪比例的影响仍有待确定。
在 5 岁时，使用双能 X 射线吸收法比较 OGDM（n=25）和血糖正常母亲的后代（n=49）的身体成分。在校正了母亲的孕前体重指数（BMI）后，分析了 100g 口服葡萄糖耐量试验（OGTT）期间的母体血糖浓度与局部脂肪量或比例的关系。
OGDM 与对照组的 BMI 相当（中位数，16.0kg/m2 vs. 16.1kg/m2）。与对照组相比，OGDM 的总脂肪量、躯干脂肪量和腿部脂肪量更高（3769g vs. 2245g，P=0.004；1289g vs. 870g，P=0.017；1638g vs. 961g，P=0.002），而 OGDM 的总瘦体重较低（15688g vs. 16941g，P=0.001）。在 OGDM 中，总脂肪量和躯干脂肪量与妊娠期间母亲 100g OGTT 的空腹和 3 小时血糖浓度相关（总脂肪量，r=0.49，P=0.018[空腹]，r=0.473，P=0.023[3 小时]；躯干脂肪量，r=0.571，P=0.004[空腹]，r=0.558，P=0.006[3 小时]），但 OGDM 腿部脂肪量与妊娠期间的母体 OGTT 之间无相关性。局部脂肪指数与同期母亲 75g OGTT 值无相关性。
宫内高血糖与 OGDM 年龄为 5 岁时的脂肪量增加有关，尤其是躯干脂肪。
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