Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL.
Department of Medicine, Division of Pulmonary Critical Care and Sleep Medicine, University of Florida College of Medicine, Gainesville, FL; and.
Blood. 2021 Apr 8;137(14):1871-1878. doi: 10.1182/blood.2020008911.
Stimulator of interferon genes (STING) is an innate immune sensor of cytoplasmic dsDNA originating from microorganisms and host cells. STING plays an important role in the regulation of murine graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and may be similarly activated during other transplantation modalities. In this review, we discuss STING in allo-HSCT and its prospective involvement in autologous HSCT (auto-HSCT) and solid organ transplantation (SOT), highlighting its unique role in nonhematopoietic, hematopoietic, and malignant cell types.
干扰素基因刺激物 (STING) 是一种细胞质双链 DNA 的先天免疫传感器，来源于微生物和宿主细胞。STING 在异基因造血干细胞移植 (allo-HSCT) 后调节小鼠移植物抗宿主病 (GVHD) 中发挥重要作用，并且在其他移植方式中可能类似地被激活。在这篇综述中，我们讨论了 allo-HSCT 中的 STING 及其在自体造血干细胞移植 (auto-HSCT) 和实体器官移植 (SOT) 中的潜在作用，强调了其在非造血、造血和恶性细胞类型中的独特作用。
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