Division of Blood and Marrow Transplantation and Cellular Therapy, Department of Medicine, Stanford University School of Medicine, Stanford, CA.
Blood. 2024 Oct 10;144(15):1557-1569. doi: 10.1182/blood.2024024219.
The microbiota, comprising bacteria, fungi, and viruses residing within our bodies, functions as a key modulator in host health and states, including immune responses. Studies have linked microbiota and microbiota-derived metabolites to immune cell functions. In this review, we probe the complex relationship between the human microbiota and clinical outcomes of cellular therapies that leverage immune cells to fight various cancers. With a particular emphasis on hematopoietic cell transplantation and chimeric antigen receptor T-cell therapy, we explore the potential mechanisms underpinning this interaction. We also highlight the interventional applications of the microbiota in cellular therapy while outlining future research directions in the field.
微生物组由存在于我们体内的细菌、真菌和病毒组成，是调节宿主健康和状态的关键因素，包括免疫反应。研究已经将微生物组和微生物衍生代谢物与免疫细胞功能联系起来。在这篇综述中，我们探讨了人类微生物组与利用免疫细胞对抗各种癌症的细胞疗法的临床结果之间的复杂关系。特别强调造血细胞移植和嵌合抗原受体 T 细胞疗法，我们探索了这种相互作用的潜在机制。我们还强调了微生物组在细胞治疗中的干预应用，同时概述了该领域的未来研究方向。
