Department of Internal Medicine, University of Uyo Teaching Hospital, Uyo, Nigeria.
Rheumatology Department, Dumfries and Galloway Royal Infirmary, Cargenbridge, Dumfries, UK.
Clin Rheumatol. 2021 Aug;40(8):3135-3141. doi: 10.1007/s10067-021-05605-x. Epub 2021 Feb 22.
Osteoarthritis (OA) is a common degenerative condition leading to significant pain, functional limitation, and economic loss. Generalized OA (GOA) is associated with greater morbidity and accounts for 5-25% of total OA cases depending on definition used. This paper aims to determine the frequency and pattern of GOA, compare clinical and laboratory parameters of GOA and non-GOA subjects, then identify independent associations of GOA among Nigerians with knee OA.
A cross-sectional study of 180 knee OA patients with knee and generalized OA defined using ACR criteria. Questionnaire administration was followed by physical examination and appropriate radiographs. Data was summarized using tables and figures. Multivariate regression was done to identify independent GOA associations with statistical significance p<0.05. Ethical approval was obtained for the study.
There were 180 participants with mean age 59.7±9.1 years. Twenty-eight patients (15.6%) had GOA of which 26 were female. The hip/knee/spine pattern was the commonest while hand OA was rare. Comparisons showed that GOA patients were significantly older with longer pain duration, higher pain score, more Heberden's nodes, and greater fatigue. There were no significant differences between both groups in levels of inflammatory markers and other laboratory parameters. Further analysis identified joint stiffness as the only independent association of GOA (OR 3.34, p=0.01).
A 15.6% frequency of GOA was identified among knee OA sufferers with the hip/knee/spine pattern most frequent. Nigerians with GOA are predominantly females with a large joint phenotype. Joint stiffness was the only independent association of GOA observed. Key Points • Generalized osteoarthritis occurs in 15.6% of Nigerian patients with knee osteoarthritis. • Females are predominantly affected with a large joint phenotype involving the hip/knee/spine. • Joint stiffness is an independent association of generalized osteoarthritis.
骨关节炎（OA）是一种常见的退行性疾病，会导致严重的疼痛、功能受限和经济损失。全身性 OA（GOA）与更高的发病率相关，占总 OA 病例的 5-25%，具体取决于使用的定义。本文旨在确定 GOA 的频率和模式，比较 GOA 和非 GOA 患者的临床和实验室参数，然后确定尼日利亚膝骨关节炎患者中 GOA 的独立关联。
对 180 例膝关节 OA 患者进行横断面研究，膝关节和全身性 OA 采用 ACR 标准定义。在进行体格检查和适当的 X 光检查后，进行问卷调查。使用表格和图形总结数据。采用多元回归分析确定 GOA 的独立关联，具有统计学意义的 p<0.05。该研究获得了伦理批准。
共有 180 名参与者，平均年龄 59.7±9.1 岁。28 名患者（15.6%）患有 GOA，其中 26 名女性。最常见的是髋膝脊柱模式，而手部 OA 则很少见。比较显示，GOA 患者年龄明显较大，疼痛持续时间较长，疼痛评分较高，Heberden 结节较多，疲劳感更严重。两组之间的炎症标志物和其他实验室参数水平没有显著差异。进一步分析发现关节僵硬是 GOA 的唯一独立关联（OR 3.34，p=0.01）。
在膝骨关节炎患者中，发现 15.6%的 GOA 频率，髋膝脊柱模式最常见。尼日利亚 GOA 患者主要为女性，表现为大关节表型。关节僵硬是 GOA 的唯一独立关联。关键点：
尼日利亚患有膝骨关节炎的患者中，15.6%发生全身性骨关节炎。
女性受影响的居多，表现为累及髋、膝、脊柱的大关节表型。
关节僵硬是全身性骨关节炎的独立关联。
