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大鼠椎前和椎旁交感神经元的形态计量学研究:随年龄的变化

Morphometric studies on pre- and paravertebral sympathetic neurons in the rat: changes with age.

作者信息

Baker D M, Santer R M

机构信息

Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, U.K.

出版信息

Mech Ageing Dev. 1988 Feb;42(2):139-45. doi: 10.1016/0047-6374(88)90069-3.

DOI:10.1016/0047-6374(88)90069-3
PMID:3361966
Abstract

Morphometric measurements have been made on rat sympathetic neurons at ages between 6 and 24 months. In neurons of the coeliac-superior mesenteric ganglion there is a marked decrease in the neuronal packing density between 12 and 18 months which is accompanied by increases in the size of the neurons and their nuclei. In the superior cervical ganglion, no changes in packing density are seen until 18 months after which a decrease occurs, accompanied by slight increases in the neuronal parameters. These post-maturation changes occurring throughout adult life reveal a continued dynamism of sympathetic neurons into old age as well as revealing further differences between populations of sympathetic neurons.

摘要

已对6至24个月大的大鼠交感神经元进行了形态测量。在腹腔-肠系膜上神经节的神经元中,12至18个月之间神经元堆积密度显著降低,同时神经元及其细胞核大小增加。在颈上神经节中,直到18个月时才观察到堆积密度的变化,之后出现降低,并伴有神经元参数的轻微增加。这些在成年期发生的成熟后变化揭示了交感神经元在老年期仍持续具有动态变化,同时也揭示了交感神经元群体之间的进一步差异。

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