Wetmore S J, Henderson C, Doshier N W, Milligan L B
Department of Otolaryngology and Maxillofacial Surgery, University of Arkansas for Medical Sciences, Little Rock 72205.
Laryngoscope. 1988 May;98(5):499-501. doi: 10.1288/00005537-198805000-00004.
Auditory brainstem response (ABR) has been used by several investigators to study the role of the brain stem in the pathophysiology of obstructive sleep apnea (OSA). These studies have produced conflicting results. We studied 27 preoperative OSA patients and 17 controls using click stimuli presented at a slow (11.7/second) rate and at a fast (57.7/second) rate. ABR was repeated postoperatively in 18 patients. There were no statistically significant differences in the ABRs of preoperative OSA patients when compared with the control group. However, the preoperative recordings showed statistically significant prolonged latencies for wave III (p less than 0.01) and interpeak latency (IPL) I-III (p less than 0.01) when compared to postoperative recordings. Rapid-rate testing was not helpful. Although normal sleep does not cause ABR abnormalities, the pathological sleepiness seen in OSA patients may cause brainstem dysfunction manifested by prolonged ABR latencies. These abnormalities may resolve with treatment of OSA.
几位研究人员已使用听觉脑干反应（ABR）来研究脑干在阻塞性睡眠呼吸暂停（OSA）病理生理学中的作用。这些研究得出了相互矛盾的结果。我们使用以慢速（每秒11.7次）和快速（每秒57.7次）呈现的点击刺激，对27例术前OSA患者和17例对照进行了研究。18例患者术后重复进行了ABR检查。术前OSA患者的ABR与对照组相比无统计学显著差异。然而，与术后记录相比，术前记录显示III波潜伏期（p小于0.01）和峰间潜伏期（IPL）I-III（p小于0.01）在统计学上有显著延长。快速率测试并无帮助。虽然正常睡眠不会导致ABR异常，但OSA患者出现的病理性嗜睡可能会导致脑干功能障碍，表现为ABR潜伏期延长。这些异常可能会随着OSA的治疗而得到解决。
