Handal Nina, Whitworth Jimmy, Blomfeldt Anita, Espvik Heidi Johanne, Lysaker Elisabeth, Berdal Jan Erik, Bakken Jørgensen Silje
Division for Diagnostics and Technology, Department of Microbiology and Infection Control, Akershus University Hospital, Lørenskog, Norway.
Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.
Infect Dis (Lond). 2021 Jun;53(6):420-429. doi: 10.1080/23744235.2021.1885734. Epub 2021 Feb 23.
A year into the pandemic, the knowledge of SARS-CoV-2 infection risks among healthcare workers remains limited. In this cross-sectional study, we examined whether healthcare workers with high exposure to Covid-19 patients had a higher risk of SARS-CoV-2 infection than other healthcare workers in a Norwegian University Hospital. We also investigated the prevalence of asymptomatic healthcare workers in a ward with a SARS-CoV-2 outbreak.
Healthcare workers from five wards at Akershus University Hospital were included between May 11 and June 11, 2020. Blood samples were analyzed for SARS-CoV-2 antibodies and seroprevalences compared between participants with high and low exposure to Covid-19 patients. Demographic data and SARS-CoV-2 infection risk factors were recorded in a questionnaire. Naso-/oropharyngeal swabs from participants from the outbreak ward were analyzed by reverse transcriptase-polymerase chain reaction.
360/436 (82.6%) healthcare workers participated. 9/262 (3.4%) participants from wards with high exposure to Covid-19 patients were SARS-CoV-2 seropositive versus 3/98 (3.1%) from wards with low exposure (OR 1.13; 95%CI 0.3-4.26, = .861). SARS-CoV-2 antibodies were found in 11/263 (4.2%) participants who had worked one or more shifts caring for Covid-19 patients versus in 1/85 (1.2%) without any known occupational Covid-19 exposure (OR 3.67; 95%CI 0.46-29.06, = .187). SARS-CoV-2 was detected in naso-/oropharyngeal swabs from 2/78 (2.6%) participants.
We found no significantly increased risk of SARS-CoV-2 infection in healthcare workers with high exposure to COVID-19 patients. Five healthcare workers had either serologic or molecular evidence of past or present unrecognized SARS-CoV-2 infection.
在新冠疫情爆发一年之际，医护人员对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染风险的了解仍然有限。在这项横断面研究中，我们调查了在挪威一家大学医院中，与新冠肺炎患者有高接触的医护人员感染SARS-CoV-2的风险是否高于其他医护人员。我们还调查了在一个发生SARS-CoV-2疫情的病房中无症状医护人员的患病率。
纳入了2020年5月11日至6月11日期间来自阿克什胡斯大学医院五个病房的医护人员。对血液样本进行SARS-CoV-2抗体分析，并比较与新冠肺炎患者有高接触和低接触的参与者之间的血清阳性率。通过问卷调查记录人口统计学数据和SARS-CoV-2感染风险因素。对来自疫情病房的参与者的鼻咽拭子进行逆转录聚合酶链反应分析。
360/436（82.6%）名医护人员参与了研究。在与新冠肺炎患者有高接触的病房中，9/262（3.4%）的参与者SARS-CoV-2血清学检测呈阳性，而在低接触病房中为3/98（3.1%）（比值比1.13；95%置信区间0.3 - 4.26，P = 0.861）。在曾护理过新冠肺炎患者一个或多个班次的11/263（4.2%）参与者中发现了SARS-CoV-2抗体，而在无任何已知职业性新冠肺炎接触的1/85（1.2%）参与者中发现了抗体（比值比3.67；95%置信区间0.46 - 29.06，P = 0.187）。在2/78（2.6%）参与者的鼻咽拭子中检测到了SARS-CoV-2。
我们发现与新冠肺炎患者有高接触的医护人员感染SARS-CoV-2的风险没有显著增加。五名医护人员有过去或现在未被识别的SARS-CoV-
