Reigel C E, Jobe P C, Dailey J W, Stewart J J
Department of Basic Sciences, University of Illinois College of Medicine, Peoria 61656.
Life Sci. 1988;42(18):1743-9. doi: 10.1016/0024-3205(88)90040-9.
The sensitivity to intracerebroventricular morphine-induced convulsions was determined in members of the severe seizure (GEPR-9) and moderate seizure (GEPR-3) colonies of genetically epilepsy-prone rats as well as in non-epileptic control rats. GEPR-9s were more sensitive to morphine-induced wet-dog shakes, rearing with bilateral forelimb clonus and generalized clonus than controls of GEPR-3s. GEPR-3s were less sensitive to morphine-induced wet-dog shakes and rearing with bilateral forelimb clonus than controls. Both high and extremely low doses of morphine in GEPR-9s elicited tonic extensor convulsions resembling the characteristic sound-induced convulsion of GEPR-9s. The results suggest that opiotergic systems may contribute to the pathophysiology of the seizure-prone condition in GEPR-9s. Further, differences in responsiveness of opiotergic systems in GEPR-3s and GEPR-9s may partially account for differences in seizure severity in the characteristic sound-induced seizures of these two types of GEPRs.
在严重癫痫发作（GEPR - 9）和中度癫痫发作（GEPR - 3）的遗传性癫痫易感大鼠群体以及非癫痫对照大鼠中，测定了对脑室内注射吗啡诱发惊厥的敏感性。与GEPR - 3对照大鼠相比，GEPR - 9对吗啡诱发的湿狗样抖动、伴有双侧前肢阵挛的竖尾和全身性阵挛更为敏感。与对照大鼠相比，GEPR - 3对吗啡诱发的湿狗样抖动和伴有双侧前肢阵挛的竖尾不太敏感。GEPR - 9中高剂量和极低剂量的吗啡均可引发强直性伸展惊厥，类似于GEPR - 9特有的声音诱发惊厥。结果表明，阿片能系统可能参与了GEPR - 9癫痫易感状态的病理生理过程。此外，GEPR - 3和GEPR - 9中阿片能系统反应性的差异可能部分解释了这两种类型GEPR特征性声音诱发癫痫发作严重程度的差异。
