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闭孔神经阻滞下单极与双极经尿道膀胱侧壁肿瘤切除术:单中心前瞻性随机研究。

Monopolar versus bipolar transurethral resection of lateral wall-located bladder cancer under obturator nerve block: a single center prospective randomized study.

机构信息

University of Health Sciences, Bozyaka Training and Research Hospital, Izmir, Turkey.

出版信息

Int Braz J Urol. 2021 May-Jun;47(3):584-593. doi: 10.1590/S1677-5538.IBJU.2020.0568.

Abstract

INTRODUCTION

The aim of the present prospective-randomized study was to compare perioperative outcomes and complications of bipolar and monopolar TURBT for lateral wall-located non-muscle invasive bladder cancers (NMIBC) under obturator nerve block (ONB).

PATIENTS AND METHODS

80 patients who underwent TURBT for lateral wall-located primary bladder tumors under ONB from March, 2016 to November, 2019 were included in the present study. The patients were randomized equally into two groups; monopolar TUR (M-TURBT) and bipolar TUR (B-TURBT). The primary and secondary outcomes were safety (obturator jerk and bladder perforation) and efficacy (complete tumor resection and sampling of the deep muscle tissue).

RESULTS

Obturator jerk was detected in 2 patients (5%) in M-TURBT while obturator jerk was not observed during B-TURBT (p=0.494). Bladder perforation was not observed in both groups. All of the patients underwent complete tumor resection. There was no significant difference in muscle tissue sampling (67.5% vs. 72.5%, p=0.626) and thermal tissue damage rates (12.5% vs. 25%, p=0.201). The majority of complications were low-grade and the differences in Clavien grade 1-3 complications between groups were not statistically significant.

CONCLUSION

In the treatment of lateral-wall located NMIBCs, either M-TURBT or B-TURBT can be safely and effectively performed by combining spinal anesthesia with ONB. Even so, it should be taken into consideration that low-grade postoperative hemorrhagic complications may occur in patients who undergo M-TURBT.

摘要

介绍

本前瞻性随机研究的目的是比较在闭孔神经阻滞(ONB)下,使用双极和单极经尿道膀胱肿瘤切除术(TURBT)治疗侧壁非肌肉浸润性膀胱癌(NMIBC)的围手术期结果和并发症。

患者和方法

本研究纳入了 2016 年 3 月至 2019 年 11 月期间在 ONB 下接受 TURBT 治疗侧壁原发性膀胱肿瘤的 80 例患者。患者被平均随机分为两组:单极 TUR(M-TURBT)和双极 TUR(B-TURBT)。主要和次要结局是安全性(闭孔神经反射和膀胱穿孔)和疗效(完全肿瘤切除和深部肌肉组织取样)。

结果

M-TURBT 中有 2 例(5%)出现闭孔神经反射,而 B-TURBT 中未观察到闭孔神经反射(p=0.494)。两组均未发生膀胱穿孔。所有患者均行完全肿瘤切除。深部肌肉组织取样(67.5% vs. 72.5%,p=0.626)和热组织损伤率(12.5% vs. 25%,p=0.201)无显著差异。大多数并发症为低级别,两组 1-3 级并发症的 Clavien 分级差异无统计学意义。

结论

在治疗侧壁 NMIBC 时,脊髓麻醉联合 ONB 可安全有效地进行 M-TURBT 或 B-TURBT。即便如此,仍应考虑到行 M-TURBT 的患者可能会发生低级别术后出血性并发症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/13e6/7993959/3c986238754b/1677-6119-ibju-47-03-0584-gf01.jpg

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