Nishiwaki H, Satake K, Ko I, Umeyama K
First Department of Surgery, Osaka City University Medical School, Japan.
Nihon Geka Gakkai Zasshi. 1988 Feb;89(2):238-44.
Pancreatic microcirculation in acute pancreatitis and the effect of dopamine and pancreatic protease inhibitor were investigated in 35 mongrel dogs. Acute pancreatitis was induced by the injection of autologous bile added trypsin into pancreatic duct. In acute pancreatitis dogs femoral artery pressure and pulse pressure gradually decreased and pancreatic microflow in basal state temporarily increased immediately after bile injection, however, thereafter continuously decreased during the experiments. Portal flow severely decreased just after onset of acute pancreatitis. By administration of dopamine femoral artery pressure was maintained during the first 90 minutes of experiments, however, thereafter decreased until the end of experiments. Pancreatic microflow, 56.1 +/- 15.3 ml/min/100g in basal level was shown 66.1 +/- 13.7 and 60.3 +/- 10.3 ml/min/100g at 1 and 2 hours, respectively, after bile injection, which were significantly high values as compared with those of non dopamine administration. However those values decreased at 5 hours of both experiments. Portal flow whose basal level was 237 +/- 67 ml/min was maintained during the first 1 hour however it decreased to 139 +/- 25 ml/min at 5 hours. By administration of pancreatic protease inhibitor femoral artery pressure and pulse pressure, temporarily decreased immediately after bile injection, however, they were maintained thereafter. Pancreatic microflow, 57.1 +/- 18.3 ml/min/100g in basal level, was maintained during the first 2 hours, however significantly decreased to 27.6 +/- 9.7 ml/min/100g at 5 hours. Portal flow significantly increased to 442 +/- 115 ml/min at 2 hours, however, thereafter decreased 219 +/- 93 ml/min at 5 hours.(ABSTRACT TRUNCATED AT 250 WORDS)
在35只杂种犬中研究了急性胰腺炎时胰腺微循环以及多巴胺和胰腺蛋白酶抑制剂的作用。通过向胰管内注射自体胆汁加胰蛋白酶诱导急性胰腺炎。在急性胰腺炎犬中，股动脉压和脉压逐渐降低，胆汁注射后基础状态下的胰腺微流量立即暂时增加，但此后在实验过程中持续下降。急性胰腺炎发作后门静脉血流严重减少。给予多巴胺后，在实验的前90分钟内股动脉压得以维持，但此后直至实验结束一直下降。基础水平为56.1±15.3 ml/min/100g的胰腺微流量，在胆汁注射后1小时和2小时分别显示为66.1±13.7和60.3±10.3 ml/min/100g，与未给予多巴胺的情况相比，这些值显著较高。然而在两个实验的5小时时这些值均下降。基础水平为237±67 ml/min的门静脉血流在最初1小时内得以维持，但在5小时时降至139±25 ml/min。给予胰腺蛋白酶抑制剂后，股动脉压和脉压在胆汁注射后立即暂时下降，但此后得以维持。基础水平为57.1±18.3 ml/min/100g的胰腺微流量在最初2小时内得以维持，但在5小时时显著降至27.6±9.7 ml/min/100g。门静脉血流在2小时时显著增加至442±115 ml/min，但此后在5小时时降至219±93 ml/min。（摘要截取自250字）
