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[大鼠体内具有类脂肪性质的各种无热量化合物的代谢]

[The metabolism of various acaloric compounds with fatlike properties in rats].

作者信息

Aust L, Mieth G, Proll J, Elsner A, Behrens H, Gerhardt W, Brückner J, Noack R

机构信息

Zentralinstitut für Ernährung in Potsdam-Rehbrücke, Akademie der Wissenschaften der DDR.

出版信息

Nahrung. 1988;32(1):49-57. doi: 10.1002/food.19880320116.

Abstract

Pseudofats as total substituted long-chain esters and ethers of polyhydroxyl compounds (sucrose, triglycerol, and polyethyleneglycol) are more or less indifferent against gastrointestinal enzymes, but display specific metabolic effects on lipid metabolism especially on cholesterol synthesis in liver, plasma lipid level, and fecal cholesterol excretion. Among the different tested compounds there exist similarities as well as differences, which are to consider as an indication for a specific relationship between structure and effect. These relations are more closely investigated and critically discussed.

摘要

作为多羟基化合物(蔗糖、甘油三酯和聚乙二醇)的全取代长链酯和醚的类脂肪对胃肠道酶或多或少无影响,但对脂质代谢尤其是肝脏胆固醇合成、血浆脂质水平和粪便胆固醇排泄具有特定的代谢作用。在不同的测试化合物中存在相似性和差异,这可被视为结构与效应之间特定关系的一个指标。对这些关系进行了更深入的研究并进行了批判性讨论。

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