耐抗生素金黄色葡萄球菌 9 型克隆复合体在猪和人类之间的传播，美国。
Transmission of Antimicrobial-Resistant Staphylococcus aureus Clonal Complex 9 between Pigs and Humans, United States.
出版信息
Emerg Infect Dis. 2021 Mar;27(3):740-748. doi: 10.3201/eid2703.191775.
Transmission of livestock-associated Staphylococcus aureus clonal complex 9 (LA-SA CC9) between pigs raised on industrial hog operations (IHOs) and humans in the United States is poorly understood. We analyzed whole-genome sequences from 32 international S. aureus CC9 isolates and 49 LA-SA CC9 isolates from IHO pigs and humans who work on or live near IHOs in 10 pig-producing counties in North Carolina, USA. Bioinformatic analysis of sequence data from the 81 isolates demonstrated 3 major LA-SA CC9 clades. North Carolina isolates all fell within a single clade (C3). High-resolution phylogenetic analysis of C3 revealed 2 subclades of intermingled IHO pig and human isolates differing by 0-34 single-nucleotide polymorphisms. Our findings suggest that LA-SA CC9 from pigs and humans share a common source and provide evidence of transmission of antimicrobial-resistant LA-SA CC9 between IHO pigs and humans who work on or live near IHOs in North Carolina.
在美国，工业化养猪场（IHO）饲养的猪与人类之间传播的与家畜相关的金黄色葡萄球菌克隆群 9（LA-SA CC9）的情况了解甚少。我们分析了来自 32 个国际金黄色葡萄球菌 CC9 分离株和 49 个来自 IHO 猪和在美国北卡罗来纳州 10 个养猪县的在 IHO 工作或居住在其附近的人类的 LA-SA CC9 分离株的全基因组序列。对 81 个分离株的序列数据进行生物信息学分析，显示出 3 个主要的 LA-SA CC9 分支。北卡罗来纳州的分离株均属于单个分支（C3）。C3 的高分辨率系统发育分析显示，IHO 猪和人类的混合分离株有 2 个亚分支，它们之间存在 0-34 个单核苷酸多态性差异。我们的研究结果表明，猪和人类的 LA-SA CC9 来自共同的来源，并提供了证据表明北卡罗来纳州 IHO 猪和在其附近工作或居住的人类之间传播了具有抗药性的 LA-SA CC9。
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