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骨软骨瘤:流行病学、发病机制、临床表现、放射学特征和治疗选择的更新综述。

Osteochondromas: An Updated Review of Epidemiology, Pathogenesis, Clinical Presentation, Radiological Features and Treatment Options.

机构信息

Department of Surgery, University Hospital of Ioannina, Ioannina, Greece;

Intensive Care Unit, University Hospital of Ioannina, Ioannina, Greece.

出版信息

In Vivo. 2021 Mar-Apr;35(2):681-691. doi: 10.21873/invivo.12308.

Abstract

Osteochondroma, the most common benign bone tumor, is a projection on the external surface of the bone, which can be sessile or pedunculated. 85% of osteochondromas present as solitary lesions, while 15% occur in the context of hereditary multiple exostoses (HME), a genetic disorder that is inherited in an autosomal dominant manner. Although often asymptomatic, symptoms may eventuate from compression of adjacent vessels or nerves, fractures, osseous deformities, bursa formation, or malignant transformation. Cartilage cap thickness >2 cm in adults or >3 cm in children as well as new onset of pain or growth, or rapid growth of the lesion, especially after the closure of the growth plate, might reflect cancerous transformation. Surgical resection is indicated for symptomatic lesions, complications, cosmetic reasons or malignant transformation. Excision of the tumor with free margin is the treatment of choice. Local recurrence is less than 2% if complete resection is achieved.

摘要

骨软骨瘤,最常见的良性骨肿瘤,是骨外表面的突起,可以是无蒂的或有蒂的。85%的骨软骨瘤表现为单发病变,而 15%发生在遗传性多发外生骨疣(HME)中,HME 是一种常染色体显性遗传的遗传疾病。尽管通常无症状,但症状可能源于邻近血管或神经受压、骨折、骨畸形、滑囊炎形成或恶变。成年人软骨帽厚度>2 厘米或儿童>3 厘米,以及新出现的疼痛或生长,或病变快速生长,尤其是在生长板闭合后,可能提示恶变。有症状的病变、并发症、美容原因或恶变需要手术切除。对于有症状、并发症、美容原因或恶变的病变,需要进行手术切除。如果完全切除,局部复发率低于 2%。

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