Tong Kai, Liu Hongzhe, Wang Xiang, Zhong Ziyi, Cao Shenglu, Zhong Chengjie, Yang YunPing, Wang Gang
Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, PR China.
Department of Spinal Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, PR China.
J Bone Oncol. 2017 Aug 30;8:23-29. doi: 10.1016/j.jbo.2017.08.002. eCollection 2017 Sep.
The geographic distribution of osteochondroma (OC) varies greatly around the world. There has been no recent report on OC in a large Chinese population. The aim of this study was to characterize OC by an epidemiological analysis of the clinical data from one medical institution in South China.
We searched medical electronic records from January 2001 to January 2016 in one large hospital in South China to identify patients with a definite diagnosis of OC. Their epidemiological data were collected and analyzed statistically, including gender, tumor site, age at first diagnosis and symptoms, local recurrence and malignant transformation. Differences between genders and between solitary osteochondroma (SO) and multiple osteochondroma (MO) were particularly analyzed.
A total of 431 OC patients (291 males and 140 females; 329 SOs and 102 MOs) were identified. The gender ratio was 2.08 with a male predominance. OCs were mostly located around the knee (250 cases). 280 patients were in their 0s to 20s upon first diagnosis. The average age at the time of first diagnosis was 20.63 years for all, 18.47 years for males and 25.11 years for females (P=0.000). OC recurred locally in 35 patients (15 SOs and 20 MOs), with a significant difference between SO/MO (P=0.000) but not between genders (P=0.100). The average interval from the primary surgery to local or malignant recurrence was 37.41 months. Malignant transformation was found in 5 patients (4 males and 1 female), showing no gender difference (P=0.549).
OC may have a male predominance in Chinese population. It mostly occurred at 0-20 years of age and around the knee. Upon the first diagnosis of OC, the males tended to be younger than the females, and so did the MO patients than the SO ones. In addition, MO had a higher incidence of local recurrence. Intervals from primary surgery to local recurrence or malignant transformation in MO patients were longer than in SO patients.
骨软骨瘤（OC）在全球的地理分布差异很大。近期尚无关于中国大量人群中骨软骨瘤的报告。本研究旨在通过对中国南方一家医疗机构的临床数据进行流行病学分析来描述骨软骨瘤的特征。
我们检索了中国南方一家大型医院2001年1月至2016年1月的医学电子记录，以确定确诊为骨软骨瘤的患者。收集并对他们的流行病学数据进行统计学分析，包括性别、肿瘤部位、首次诊断年龄和症状、局部复发和恶变。特别分析了性别之间以及孤立性骨软骨瘤（SO）和多发性骨软骨瘤（MO）之间的差异。
共确定了431例骨软骨瘤患者（男性291例，女性140例；孤立性骨软骨瘤329例，多发性骨软骨瘤102例）。性别比为2.08，男性占主导。骨软骨瘤大多位于膝关节周围（250例）。280例患者首次诊断时年龄在0至20岁之间。所有患者首次诊断时的平均年龄为20.63岁，男性为18.47岁，女性为25.11岁（P = 0.000）。35例患者（15例孤立性骨软骨瘤和20例多发性骨软骨瘤）出现局部复发，孤立性骨软骨瘤/多发性骨软骨瘤之间有显著差异（P = 0.000），但性别之间无差异（P = 0.100）。从初次手术到局部或恶性复发的平均间隔时间为37.41个月。5例患者（4例男性和1例女性）发生恶变，无性别差异（P = 0.549）。
在中国人群中，骨软骨瘤可能以男性为主。它大多发生在0至20岁，且多位于膝关节周围。首次诊断骨软骨瘤时，男性往往比女性年轻，多发性骨软骨瘤患者也比孤立性骨软骨瘤患者年轻。此外，多发性骨软骨瘤的局部复发率较高。多发性骨软骨瘤患者从初次手术到局部复发或恶变的间隔时间比孤立性骨软骨瘤患者长。
