双层纳米纤维贴片预防吻合口漏和腹膜粘连的实验研究。
Double-layered Nanofibrous Patch for Prevention of Anastomotic Leakage and Peritoneal Adhesions, Experimental Study.
机构信息
Department of Surgery, Faculty of Medicine in Pilsen, Charles University, Prague, Czech Republic;
Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Prague, Czech Republic.
出版信息
In Vivo. 2021 Mar-Apr;35(2):731-741. doi: 10.21873/invivo.12314.
BACKGROUND/AIM: Anastomotic leakage is a feared complication in colorectal surgery. Postoperative peritoneal adhesions can also cause life-threatening conditions. Nanofibrous materials showed their pro-healing properties in various studies. The aim of the study was to evaluate the impact of double-layered nanofibrous materials on anastomotic healing and peritoneal adhesions formation.
MATERIALS AND METHODS
Two versions of double-layered materials from polycaprolactone and polyvinyl alcohol were applied on defective anastomosis on the small intestine of healthy pigs. The control group remained with uncovered defect. Tissue specimens were subjected to histological analysis and adhesion scoring after 3 weeks of observation.
RESULTS
The wound healing was inferior in the experimental groups, however, no anastomotic leakage was observed and the applied material always kept covering the defect. The extent of adhesions was larger in the experimental groups.
CONCLUSION
Nanofibrous materials may prevent anastomotic leakage but delay healing.
背景/目的：肠吻合口漏是结直肠手术后一种可怕的并发症。术后腹膜粘连也可能导致危及生命的情况。在各种研究中，纳米纤维材料表现出了促进愈合的特性。本研究旨在评估双层纳米纤维材料对吻合口愈合和腹膜粘连形成的影响。
材料和方法
将两种聚己内酯和聚乙烯醇双层材料应用于健康猪小肠的缺陷吻合处。对照组保持未覆盖的缺陷。在观察 3 周后，对组织标本进行组织学分析和粘连评分。
结果
实验组的伤口愈合情况较差，但未观察到吻合口漏，且应用的材料始终覆盖缺陷。实验组的粘连程度更大。
结论
纳米纤维材料可以预防吻合口漏，但会延迟愈合。
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