根治性放化疗后中性粒细胞与淋巴细胞比值预测食管鳞癌患者的生存。
Neutrophil-to-Lymphocyte Ratio After Definitive Concurrent Chemoradiotherapy Predicts Survival in Patients With Esophageal Squamous Cell Carcinoma.
机构信息
Department of Radiation Oncology, Konkuk University School of Medicine and Konkuk University Medical Center, Seoul, Republic of Korea.
Department of Radiation Oncology/CyberKnife Center, Soonchunhyang University Seoul Hospital, Seoul, Republic of Korea.
出版信息
In Vivo. 2021 Mar-Apr;35(2):1133-1139. doi: 10.21873/invivo.12359.
BACKGROUND/AIM: Lymphocyte-to-monocyte ratio, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio represent systemic immune-inflammatory responses. We evaluated the association between immune-inflammatory cell ratios and prognosis in esophageal squamous cell carcinoma (ESCC) patients who underwent definitive concurrent chemoradiotherapy (dCCRT).
PATIENTS AND METHODS
Medical records of 68 ESCC patients in three institutions who underwent dCCRT between 2006 and 2017 were reviewed. The immune-inflammatory cell ratios were calculated before and after dCCRT.
RESULTS
The median follow-up time was 11.4 months. The 3-year overall survival (OS) rate was 21.6%. Among the immune-inflammatory cell ratios, lower post-dCCRT neutrophil-to-lymphocyte ratio (NLRpost) was associated with better OS (median 15.2 vs. 9.7 months, p=0.030). Patients with lower NLRpost had more improved OS when adjuvant chemotherapy was administered following dCCRT (median 16.6 vs. 4.8 months, p<0.001).
CONCLUSION
NLRpost may be useful in predicting OS in ESCC patients after dCCRT. Furthermore, NLRpost might play a role in establishing adjuvant therapy plans following dCCRT.
背景/目的：淋巴细胞与单核细胞比值、中性粒细胞与淋巴细胞比值和血小板与淋巴细胞比值代表全身免疫炎症反应。我们评估了在接受根治性同期放化疗（dCCRT）的食管鳞癌（ESCC）患者中，免疫炎症细胞比值与预后之间的关系。
患者与方法
回顾了 2006 年至 2017 年间在三个机构接受 dCCRT 的 68 例 ESCC 患者的病历。在 dCCRT 前后计算了免疫炎症细胞比值。
结果
中位随访时间为 11.4 个月。3 年总生存率（OS）为 21.6%。在免疫炎症细胞比值中，较低的 dCCRT 后中性粒细胞与淋巴细胞比值（NLRpost）与更好的 OS 相关（中位 15.2 与 9.7 个月，p=0.030）。在 dCCRT 后接受辅助化疗的患者中，NLRpost 较低的患者具有更好的 OS（中位 16.6 与 4.8 个月，p<0.001）。
结论
NLRpost 可能有助于预测 dCCRT 后 ESCC 患者的 OS。此外，NLRpost 可能在制定 dCCRT 后辅助治疗计划方面发挥作用。
Zotero 插件