Kimura Yutaka, Gakuhara Atsushi, Fukuda Shuichi, Fukuda Yasunari, Yoshihara Terukazu, Koga Chikato, Haraguchi Naotsugu, Hida Jin-Ichi
Department of Surgery, Kindai University Nara Hospital, 1248-1 Otoda-Cho, Ikoma, Nara, 630-0293, Japan.
Esophagus. 2025 Mar 29. doi: 10.1007/s10388-025-01117-8.
Advanced esophageal cancer is treated by chemotherapy, radiation therapy, chemoradiotherapy, and immunotherapy. However, the stenosis caused by the tumor and cancer-related chronic inflammation leads to inadequate food intake, weight loss, and nutrition problems. Given that poor pre-treatment nutritional status increases the risks of treatment-related adverse events and a poor prognosis, the nutrition guidelines recommend a pre-treatment nutritional assessment. When malnutrition is present, nutritional interventions, such as dietary guidance and enteral nutrition supplements, provided by the medical team may reduce treatment-related adverse events. However, whether nutritional intervention improves the prognosis is a topic for future research, including randomized controlled trials. This review discusses the literature on nutritional management in patients undergoing chemotherapy and chemoradiotherapy for advanced esophageal cancer.
晚期食管癌采用化疗、放疗、放化疗和免疫治疗。然而，肿瘤导致的狭窄以及癌症相关的慢性炎症会导致食物摄入不足、体重减轻和营养问题。鉴于治疗前营养状况不佳会增加治疗相关不良事件的风险和预后不良，营养指南建议进行治疗前营养评估。当存在营养不良时，医疗团队提供的营养干预措施，如饮食指导和肠内营养补充剂，可能会减少治疗相关的不良事件。然而，营养干预是否能改善预后是未来研究的一个课题，包括随机对照试验。这篇综述讨论了晚期食管癌患者接受化疗和放化疗时营养管理的相关文献。
