College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, China.
Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 610041, China.
J Mater Chem B. 2021 Mar 11;9(9):2221-2232. doi: 10.1039/d1tb00019e.
Developing ultra-stretchable, universally sticky, and highly conductive nanocomposite hydrogels without doping agents and nanoparticle-aggregation is still a challenge. Herein, doping-free and nanoparticle-aggregation-inhibited hydrogels composed of Fe3+, dopamine (DA), pyrrole (Py) and polyacrylic acid (PAA) were prepared. Polypyrrole-polydopamine (PPy-PDA)/PAA hydrogels were quickly formed due to the abundant ionic bonds and physical cross-linking under the addition of Fe3+. Moreover, the H+ ions of the carboxylic acid groups on the PAA polymer chain helped to improve the conductivity of the hydrogels. Surprisingly, the multi-functional hydrogels received a high stretchability of 1900%, a tissue-like elastic modulus of 22 kPa, an adhesive strength of 2125.9 J m-2, and a high conductivity of 0.39 S m-1. Besides, the PPy-PDA/PAA hydrogels showed good antioxidant activity, biocompatibility and tissue repairing behavior. In short, the prepared multi-functional hydrogels have potential to address the human clinical problem of tissue repair and regeneration.
制备无掺杂剂和纳米颗粒聚集的超拉伸、通用粘性和高导电性纳米复合水凝胶仍然是一个挑战。本文制备了由 Fe3+、多巴胺（DA）、吡咯（Py）和聚丙烯酸（PAA）组成的无掺杂剂和纳米颗粒聚集抑制剂水凝胶。由于添加了 Fe3+，聚吡咯-聚多巴胺（PPy-PDA）/PAA 水凝胶迅速形成，这是由于存在丰富的离子键和物理交联。此外，PAA 聚合物链上羧酸基团的 H+离子有助于提高水凝胶的导电性。令人惊讶的是，多功能水凝胶具有 1900%的高拉伸性、类似组织的弹性模量 22kPa、黏附强度 2125.9Jm-2 和 0.39Sm-1 的高导电性。此外，PPy-PDA/PAA 水凝胶表现出良好的抗氧化活性、生物相容性和组织修复行为。总之，所制备的多功能水凝胶有望解决组织修复和再生的人类临床问题。
