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Proof of concept for a rapidly switchable universal CAR-T platform with UniCAR-T-CD123 in relapsed/refractory AML.

作者信息

Wermke Martin, Kraus Sabrina, Ehninger Armin, Bargou Ralf C, Goebeler Maria-Elisabeth, Middeke Jan Moritz, Kreissig Carla, von Bonin Malte, Koedam Jan, Pehl Michael, Bornhäuser Martin, Einsele Hermann, Ehninger Gerhard, Cartellieri Marc

机构信息

Division of Hematology, Oncology and Stem Cell Transplantation, Medical Clinic I, Department of Medicine I, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany.

National Center for Tumor Diseases, Dresden, Germany.

出版信息

Blood. 2021 Jun 3;137(22):3145-3148. doi: 10.1182/blood.2020009759.

Abstract
摘要

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41BB-based and CD28-based CD123-redirected T-cells ablate human normal hematopoiesis in vivo.
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Rapidly Switchable Universal CAR-T Cells for Treatment of CD123-Positive Leukemia.
Mol Ther Oncolytics. 2020 Apr 29;17:408-420. doi: 10.1016/j.omto.2020.04.009. eCollection 2020 Jun 26.
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How close are we to CAR T-cell therapy for AML?
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