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Proof of concept for a rapidly switchable universal CAR-T platform with UniCAR-T-CD123 in relapsed/refractory AML.具有UniCAR-T-CD123的快速可切换通用CAR-T平台用于复发/难治性急性髓系白血病的概念验证
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本文引用的文献

1
American Society of Hematology 2020 guidelines for treating newly diagnosed acute myeloid leukemia in older adults.美国血液学会2020年老年初诊急性髓系白血病治疗指南。
Blood Adv. 2020 Aug 11;4(15):3528-3549. doi: 10.1182/bloodadvances.2020001920.
2
41BB-based and CD28-based CD123-redirected T-cells ablate human normal hematopoiesis in vivo.基于 41BB 和 CD28 的 CD123 导向 T 细胞在体内消除人正常造血。
J Immunother Cancer. 2020 Jun;8(1). doi: 10.1136/jitc-2020-000845.
3
Rapidly Switchable Universal CAR-T Cells for Treatment of CD123-Positive Leukemia.用于治疗CD123阳性白血病的快速可切换通用嵌合抗原受体T细胞
Mol Ther Oncolytics. 2020 Apr 29;17:408-420. doi: 10.1016/j.omto.2020.04.009. eCollection 2020 Jun 26.
4
How close are we to CAR T-cell therapy for AML?我们距离 CAR T 细胞疗法治疗 AML 还有多远？
Best Pract Res Clin Haematol. 2019 Dec;32(4):101104. doi: 10.1016/j.beha.2019.101104. Epub 2019 Oct 18.
5
A theranostic PSMA ligand for PET imaging and retargeting of T cells expressing the universal chimeric antigen receptor UniCAR.一种用于PET成像以及重定向表达通用嵌合抗原受体UniCAR的T细胞的诊疗一体化PSMA配体。
Oncoimmunology. 2019 Sep 7;8(11):1659095. doi: 10.1080/2162402X.2019.1659095. eCollection 2019.
6
Chimeric antigen receptor T-cell therapy for acute myeloid leukemia: how close to reality?嵌合抗原受体T细胞疗法治疗急性髓系白血病：离现实有多近？
Haematologica. 2019 Jul;104(7):1302-1308. doi: 10.3324/haematol.2018.208751. Epub 2019 Jun 20.
7
The UniCAR system: A modular CAR T cell approach to improve the safety of CAR T cells.UniCAR 系统：一种模块化 CAR T 细胞方法，旨在提高 CAR T 细胞的安全性。
Immunol Lett. 2019 Jul;211:13-22. doi: 10.1016/j.imlet.2019.05.003. Epub 2019 May 12.
8
Long-term safety and activity of axicabtagene ciloleucel in refractory large B-cell lymphoma (ZUMA-1): a single-arm, multicentre, phase 1-2 trial.阿基仑赛注射液治疗难治性大 B 细胞淋巴瘤的长期安全性和疗效（ZUMA-1）：一项单臂、多中心、1-2 期临床试验。
Lancet Oncol. 2019 Jan;20(1):31-42. doi: 10.1016/S1470-2045(18)30864-7. Epub 2018 Dec 2.
9
Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma.Tisagenlecleucel 治疗成人复发或难治性弥漫性大 B 细胞淋巴瘤。
N Engl J Med. 2019 Jan 3;380(1):45-56. doi: 10.1056/NEJMoa1804980. Epub 2018 Dec 1.
10
Insights into cytokine release syndrome and neurotoxicity after CD19-specific CAR-T cell therapy.细胞因子释放综合征和神经毒性的新见解：CD19 特异性嵌合抗原受体 T 细胞治疗后。
Curr Res Transl Med. 2018 May;66(2):50-52. doi: 10.1016/j.retram.2018.03.003. Epub 2018 Apr 3.

Proof of concept for a rapidly switchable universal CAR-T platform with UniCAR-T-CD123 in relapsed/refractory AML.

作者信息

Wermke Martin, Kraus Sabrina, Ehninger Armin, Bargou Ralf C, Goebeler Maria-Elisabeth, Middeke Jan Moritz, Kreissig Carla, von Bonin Malte, Koedam Jan, Pehl Michael, Bornhäuser Martin, Einsele Hermann, Ehninger Gerhard, Cartellieri Marc

机构信息

Division of Hematology, Oncology and Stem Cell Transplantation, Medical Clinic I, Department of Medicine I, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany.

National Center for Tumor Diseases, Dresden, Germany.

出版信息

Blood. 2021 Jun 3;137(22):3145-3148. doi: 10.1182/blood.2020009759.

DOI:10.1182/blood.2020009759
PMID:33624009
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8176767/
Abstract
摘要