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Co-localization of the nerve growth factor precursor protein and mRNA in the mouse submandibular gland.

作者信息

Dicou E, Lee J, Brachet P

机构信息

INSERM U.298, Centre Hospitalier Régional, Angers, France.

出版信息

Neurosci Lett. 1988 Feb 15;85(1):19-23. doi: 10.1016/0304-3940(88)90421-1.

DOI:10.1016/0304-3940(88)90421-1
PMID:3362409
Abstract

Indirect immunofluorescence on frozen sections of the mouse submandibular gland (MSG) and affinity-purified sera directed against synthetic peptides that reproduce sequences of the nerve growth factor (NGF) precursor protein permitted its localization in the basal parts of the cells forming the secretory tubules. In situ hybridization experiments employing 35S-labeled NGF cDNA probe localized the NGF mRNA in the same region. Conversion of proNGF to mature NGF results in an altered localization of the cleaved peptide throughout the cytoplasm of the tubular cells with a preferential concentration at their apical pole.

摘要

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Co-localization of the nerve growth factor precursor protein and mRNA in the mouse submandibular gland.
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Two peptides derived from the nerve growth factor precursor are biologically active.源自神经生长因子前体的两种肽具有生物活性。
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