Key Laboratory of Optoelectronic Devices and Systems of Guangdong Province and Ministry of Education, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, China.
China Japan Union Hospital of Jilin University, Changchun, China.
J Biophotonics. 2021 Jun;14(6):e202000498. doi: 10.1002/jbio.202000498. Epub 2021 Mar 3.
The mortality of high-grade serous ovarian cancer (HGSOC) accounts for 70% to 80% of all ovarian cancer deaths and overall mortality rate has not declined in the last decade. Recently, many studies have demonstrated that HGSOC originates from the fallopian tubes. The extracellular matrix (ECM) is present in all tissues, its remodeling and interaction with cells are crucial for regulating cell proliferation, migration, and differentiation. In this paper, we used label-free nonlinear optical microscopy to image tissues of the fallopian tube and ovary. Combining a set of image processing algorithms, we monitored the remodeling of ECM in the fallopian tube and ovary during the invasion of primary serous fallopian tube tumor into the ovary in microscopic dimension. With this approach, we can obtain physiological information of HGSOC at the early stage, which provided useful data for auxiliary clinical diagnosis.
高级别浆液性卵巢癌（HGSOC）的死亡率占所有卵巢癌死亡人数的 70%至 80%，而过去十年总体死亡率并未下降。最近，许多研究表明 HGSOC 源自输卵管。细胞外基质（ECM）存在于所有组织中，其重塑和与细胞的相互作用对于调节细胞增殖、迁移和分化至关重要。在本文中，我们使用无标记非线性光学显微镜对输卵管和卵巢组织进行成像。结合一组图像处理算法，我们在原发性浆液性输卵管肿瘤侵犯卵巢的微观尺度上，监测了输卵管和卵巢中 ECM 的重塑。通过这种方法，我们可以在早期获得 HGSOC 的生理信息，为辅助临床诊断提供了有用的数据。
