Capstone College of Nursing, The University of Alabama, Tuscaloosa, AL, USA.
Department of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA.
AIDS Care. 2022 Jun;34(6):679-688. doi: 10.1080/09540121.2021.1889953. Epub 2021 Feb 24.
Chronic pain commonly occurs in people living with HIV (PLWH). Many PLWH in the United States obtain opioids for chronic pain management. Whether insomnia severity and depressive symptoms are exacerbated by chronic pain and opioid use in PLWH remains to be determined. This study examined insomnia severity and depressive symptoms in 85 PLWH with chronic pain and 35 PLWH without chronic pain. Among PLWH with chronic pain, reported opioid use was examined in relation to insomnia severity and depressive symptoms. PLWH with chronic pain reported significantly greater insomnia severity ( = .033) and depressive symptoms ( = .025) than PLWH without chronic pain. Among PLWH with chronic pain who reported opioid use ( = 36), insomnia severity was greater compared to those who denied opioid use ( = 49), even after controlling for pain severity and number of comorbidities ( = .026). Greater pain severity was significantly associated with greater insomnia severity ( < .001) and depressive symptoms ( = .048) among PLWH with chronic pain who reported opioid use. These associations were not significant among those PLWH with chronic pain who denied opioid use. Findings suggest that PLWH with chronic pain are likely to experience poor sleep and depressed mood. Furthermore, poor sleep was associated with opioid use among PLWH with chronic pain.
慢性疼痛在艾滋病毒感染者（PLWH）中很常见。许多美国的 PLWH 因慢性疼痛管理而获得阿片类药物。PLWH 慢性疼痛和阿片类药物使用是否会加剧失眠严重程度和抑郁症状仍有待确定。本研究检查了 85 名慢性疼痛的 PLWH 和 35 名无慢性疼痛的 PLWH 的失眠严重程度和抑郁症状。在患有慢性疼痛的 PLWH 中，研究了报告的阿片类药物使用与失眠严重程度和抑郁症状的关系。与无慢性疼痛的 PLWH 相比，患有慢性疼痛的 PLWH 报告的失眠严重程度（ = .033）和抑郁症状（ = .025）明显更高。在报告使用阿片类药物的慢性疼痛 PLWH 中（ = 36），与否认使用阿片类药物的 PLWH 相比（ = 49），失眠严重程度更高，即使在控制疼痛严重程度和合并症数量后也是如此（ = .026）。在报告使用阿片类药物的慢性疼痛 PLWH 中，疼痛严重程度与失眠严重程度（ < .001）和抑郁症状（ = .048）显著相关。在否认使用阿片类药物的慢性疼痛 PLWH 中，这些关联并不显著。研究结果表明，慢性疼痛的 PLWH 可能会经历睡眠质量差和情绪低落。此外，在慢性疼痛的 PLWH 中，睡眠质量差与阿片类药物的使用有关。
